In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.

Autor:	Haukvik UK; Department of Adult Mental Health, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Gurholt TP; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway., Nerland S; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway., Elvsåshagen T; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Akudjedu TN; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.; Institute of Medical Imaging & Visualisation, Faculty of Health & Social Sciences, Bournemouth University, Bournemouth, UK., Alda M; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; National Institute of Mental Health, Klecany, Czech Republic., Alnaes D; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Alonso-Lana S; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain., Bauer J; Institute of Clinical Radiology, University of Münster, Münster, Germany., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia., Benedetti F; Psychiatry and Clinical Psychobiology, Scientific Institute Ospedale San Raffaele, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy., Berk M; Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia.; Orygen, The National Centre of Excellence in Youth Mental Health and Centre for Youth Mental Health, the Department of Psychiatry and the Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia., Bettella F; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Bøen E; Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Bonnín CM; Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain., Brambilla P; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Canales-Rodríguez EJ; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain., Cannon DM; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Caseras X; MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Dandash O; Brain, Mind and Society Research Hub, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia., Dannlowski U; Department of Psychiatry, University of Münster, Münster, Germany., Delvecchio G; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Díaz-Zuluaga AM; Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia., van Erp TGM; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, USA.; Center for the Neurobiology of Learning, University of California Irvine and Memory, Irvine, California, USA., Fatjó-Vilas M; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain., Foley SF; Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK., Förster K; Department of Psychiatry, University of Münster, Münster, Germany., Fullerton JM; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Goikolea JM; Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain., Grotegerd D; Department of Psychiatry, University of Münster, Münster, Germany., Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany., Haarman BCM; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Haatveit B; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Hajek T; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; National Institute of Mental Health, Klecany, Czech Republic., Hallahan B; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Harris M; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Hawkins EL; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Howells FM; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.; Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa., Hülsmann C; Department of Psychiatry, University of Münster, Münster, Germany., Jahanshad N; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA., Jørgensen KN; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway., Kircher T; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Marburg, Germany., Krämer B; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany., Krug A; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Marburg, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Kuplicki R; Laureate Institute for Brain Research, Tulsa, Oklahoma, USA., Lagerberg TV; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Lancaster TM; Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.; School of Psychology, Bath University, Bath, UK., Lenroot RK; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; University of New Mexico, Albuquerque, New Mexico, USA., Lonning V; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway., López-Jaramillo C; Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.; Mood Disorders Program, Hospital Universitario San Vicente Fundación, Medellín, Antioquia, Colombia., Malt UF; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., McDonald C; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., McPhilemy G; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., van der Meer D; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Melle I; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Melloni EMT; Psychiatry and Clinical Psychobiology, Scientific Institute Ospedale San Raffaele, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy., Mitchell PB; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Black Dog Institute, Sydney, New South Wales, Australia., Nabulsi L; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland., Nenadić I; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Marburg, Germany., Oertel V; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Oldani L; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Opel N; Department of Psychiatry, University of Münster, Münster, Germany., Otaduy MCG; LIM44, Department of Radiology and Oncology, University of São Paulo, São Paulo, Brazil., Overs BJ; Neuroscience Research Australia, Randwick, New South Wales, Australia., Pineda-Zapata JA; Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.; Research Group, Instituto de Alta Tecnología Médica, Medellín, Antioquia, Colombia., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain., Radua J; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden., Rauer L; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany., Redlich R; Department of Psychiatry, University of Münster, Münster, Germany., Repple J; Department of Psychiatry, University of Münster, Münster, Germany., Rive MM; Psychiatry, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Roberts G; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Black Dog Institute, Sydney, New South Wales, Australia., Ruhe HG; Psychiatry, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.; Department of Psychiatry, Radboudumc, Nijmegen, The Netherlands., Salminen LE; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA., Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain., Sarró S; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain., Savitz J; Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.; Oxley College of Health Sciences, The University of Tulsa, Tulsa, Oklahoma, USA., Schene AH; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.; Department of Psychiatry, Radboudumc, Nijmegen, The Netherlands., Sim K; West Region/Institute of Mental Health, Singapore, Singapore.; Yong Loo Lin School of Medicine/National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine/Nanyang Technological University, Singapore, Singapore., Soeiro-de-Souza MG; Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil., Stäblein M; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Stein DJ; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.; Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa.; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa., Stein F; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Marburg, Germany., Tamnes CK; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway., Temmingh HS; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.; General Adult Psychiatry Division, Valkenberg Hospital, Cape Town, Western Cape, South Africa., Thomopoulos SI; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA., Veltman DJ; Department of Psychiatry, Amsterdam UMC, Location VUMC, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Vieta E; Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Waltemate L; Department of Psychiatry, University of Münster, Münster, Germany., Westlye LT; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Whalley HC; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Sämann PG; Max Planck Institute of Psychiatry, Munich, Germany., Thompson PM; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA., Ching CRK; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA., Andreassen OA; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Agartz I; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
Jazyk:	angličtina
Zdroj:	Human brain mapping [Hum Brain Mapp] 2022 Jan; Vol. 43 (1), pp. 385-398. Date of Electronic Publication: 2020 Oct 19.
DOI:	10.1002/hbm.25249
Abstrakt:	The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD. (© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
Databáze:	MEDLINE
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