Biobanking for COVID-19 research.

Autor: Rovere-Querini P; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy - rovere.patrizia@hsr.it.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy - rovere.patrizia@hsr.it., Tresoldi C; Unit of Molecular Hematology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Conte C; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Ruggeri A; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Ghezzi S; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., DE Lorenzo R; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., DI Filippo L; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., Farina N; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy., Ramirez GA; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Ripa M; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Mancini N; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Laboratory of Microbiology and Virology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Cantarelli E; Diabetes Research Institute, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Galli L; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Poli A; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., DE Cobelli F; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Unit of Radiology, Experimental Imaging Center, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Bonini C; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Manfredi AA; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Franchini S; Emergency Department, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Spessot M; Emergency Department, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Carlucci M; Emergency Department, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Dagna L; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Scarpellini P; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Ambrosio A; Division of Clinical Governance, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., DI Napoli D; Division of Clinical Governance, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Bosi E; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Tresoldi M; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Lazzarin A; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Landoni G; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Martino G; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Zangrillo A; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Poli G; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Castagna A; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Vicenzi E; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Clementi M; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Laboratory of Microbiology and Virology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Ciceri F; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Jazyk: angličtina
Zdroj: Panminerva medica [Panminerva Med] 2022 Jun; Vol. 64 (2), pp. 244-252. Date of Electronic Publication: 2020 Oct 19.
DOI: 10.23736/S0031-0808.20.04168-3
Abstrakt: Background: Biobanks are imperative infrastructures, particularly during outbreaks, when there is an obligation to acquire and share knowledge as quick as possible to allow for implementation of science-based preventive, diagnostic, prognostic, and therapeutic strategies.
Methods: We established a COVID-19 biobank with the aim of collecting high-quality and well-annotated human biospecimens, in the effort to understand the pathogenic mechanisms underlying COVID-19 and identify therapeutic targets (COVID-BioB, NCT04318366). Here we describe our experience and briefly review the characteristics of the biobanks for COVID-19 that have been so far established.
Results: A total of 46,677 samples have been collected from 913 participants (63.3% males, median [IQR] age 62.2 [51.2-74.0] years) since the beginning of the program. Most patients (66.9%) had been admitted to hospital for COVID-19, with a median length of stay of 15.0 (9.0-27.0) days. A minority of patients (13.3% of the total) had been admitted for other reasons and subsequently tested positive for SARS-CoV-2. The remainder were managed at home after being seen at the Emergency Department.
Conclusions: Having a solid research infrastructure already in place, along with flexibility and adaptability to new requirements, allowed for the quick building of a COVID-19 biobank that will help expand and share the knowledge of SARS-CoV-2.
Databáze: MEDLINE
Externí odkaz: