Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine.

Autor: Gramatiuk SM; Department of Clinical Research, Ukraine Association of Biobank, Kharkiv, Ukraine., Bagmut IY; Department of Clinical Pathophysiology, Topographic Anatomy and Operative Surgery, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine., Ivanova JV; Surgery Department No. 1, Institute of General and Urgent Surgery of V.T. Zaytsev National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine., Tymchenko MY; Surgery Department No. 1, Institute of General and Urgent Surgery of V.T. Zaytsev National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine., Kryvorotko IV; Surgery Department No. 1, Institute of General and Urgent Surgery of V.T. Zaytsev National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine., Pak SO; Department of Perinatology, Obstetrics and Gynecology, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine., Sheremet MI; Surgery Department No. 1, Bukovinian State Medical University, Chernivtsi, Ukraine.
Jazyk: angličtina
Zdroj: Journal of medicine and life [J Med Life] 2020 Jul-Sep; Vol. 13 (3), pp. 371-377.
DOI: 10.25122/jml-2020-0083
Abstrakt: The study of the incidence of cryoglobulinemia is relevant in patients with an intestinal anastomotic leak. This study aims to determine a laboratory marker of the risk of small intestine anastomotic leak. The study was based on 96 patients who were subjected to resections of segments of the small intestine with the formation of intestinal anastomoses at the State Institution "Zaytsev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine". Of all the operated patients, there were 55.2% women and 44.8% men. Of the 96 patients examined, cryoglobulinemia was detected in the majority - 62.5% of patients, of which 4 were later proved to have inactive hepatitis C; the remaining 38.5% had no cryoglobulinemia. According to the existing theory of the autoimmune mechanism of postoperative surgical complications formation, the revealed decrease in the level of cryoglobulins on the second day could be related to their fixation in the microcirculatory bed and the development of immunocomplex inflammation. While the increase in the content of cryoglobulins in serum on the third day can be caused by their entry into the circulatory bed from deposition or fixation sites and the development of a secondary immune response. In patients with intestinal anastomosis failure after resection of intestinal segments, cryoglobulinemia rates increased more than 80 mg/l; this indicator could be used as a marker of postoperative complications.
(©Carol Davila University Press.)
Databáze: MEDLINE
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