Application of autologous endometrial mesenchymal stromal/stem cells increases thin endometrium receptivity: a case report.

Autor: Sapozhak IM; Biotechnology Laboratory Ilaya.Regeneration, Medical Company Ilaya, I. Kramskogo Street, 9, Kiev, 03115, Ukraine.; Biotechnology Laboratory, Medical Company 'Good Cells', I. Kramskogo Street 9, Kiev, 03115, Ukraine., Gubar ОS; Biotechnology Laboratory Ilaya.Regeneration, Medical Company Ilaya, I. Kramskogo Street, 9, Kiev, 03115, Ukraine.; Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Zabolotnogo Street, 150, Kiev, 03143, Ukraine., Rodnichenko AE; Biotechnology Laboratory Ilaya.Regeneration, Medical Company Ilaya, I. Kramskogo Street, 9, Kiev, 03115, Ukraine.; Biotechnology Laboratory, Medical Company 'Good Cells', I. Kramskogo Street 9, Kiev, 03115, Ukraine.; State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Vyshgorodskaja Street, 67, Kiev, 04114, Ukraine., Zlatska AV; Biotechnology Laboratory Ilaya.Regeneration, Medical Company Ilaya, I. Kramskogo Street, 9, Kiev, 03115, Ukraine. alenazlacka@gmail.com.; Biotechnology Laboratory, Medical Company 'Good Cells', I. Kramskogo Street 9, Kiev, 03115, Ukraine. alenazlacka@gmail.com.; State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Vyshgorodskaja Street, 67, Kiev, 04114, Ukraine. alenazlacka@gmail.com.
Jazyk: angličtina
Zdroj: Journal of medical case reports [J Med Case Rep] 2020 Oct 17; Vol. 14 (1), pp. 190. Date of Electronic Publication: 2020 Oct 17.
DOI: 10.1186/s13256-020-02515-5
Abstrakt: Background: Pregnancy in cycles with the use of assisted reproductive technologies is possible only with the availability of good-quality embryos and a healthy receptive endometrium. The problem of lack of sensitivity of the endometrium is related to the syndrome of thin endometrium, which is caused by a number of factors. However, there is no single protocol for the treatment of this syndrome, the return/improvement of normal functionality of endometrial tissue, and obtaining the desired pregnancy.
Case Presentation: We report a case of a 38-year-old Ukrainian woman with a number of unsuccessful tries at pregnancy in cycles with the use of assisted reproductive technologies. We describe a clinical case of the use of mesenchymal stem cells of the human endometrium for a woman with thin endometrial syndrome to increase its receptivity for pregnancy. The basic steps of patient management, protocol of sampling material for obtaining a cell product based on endometrial stem cells, their basic morphofunctional characteristics, and post-treatment procedures to obtain the desired pregnancy are described.
Conclusion: Application of autologous endometrial mesenchymal stem cells increases endometrial receptivity and the chance for pregnancy with use of assisted reproductive technologies.
Databáze: MEDLINE
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