Predictive Role of Biopsy Based Biomarkers for Radiotherapy Treatment in Rectal Cancer.

Autor:	Wen Y; Department of General Surgery, Shanghai General, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China.; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden., Zhao S; Department of General Surgery, Shanghai General, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China.; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden., Holmqvist A; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden., Hahn-Stromberg V; Department of Medical Cell Biology, Uppsala University, SE-751 05 Uppsala, Sweden., Adell G; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden., Holmlund B; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden., Pathak S; Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, Chennai 603 103, India., Peng Z; Department of General Surgery, Shanghai General, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China., Sun XF; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2020 Oct 13; Vol. 10 (4). Date of Electronic Publication: 2020 Oct 13.
DOI:	10.3390/jpm10040168
Abstrakt:	Background and Purpose: Radiation therapy has long been contemplated as an important mode in the treatment of rectal cancer. However, there are few ideal tools available for clinicians to make a radiotherapy decision at the time of diagnosis for rectal cancer. The purpose of this study was to assess whether biomarkers expressed in the biopsy could help to choose the suitable therapy and provide predictive and/or prognostic information. Experimental Design: In total, 30 biomarkers were analyzed in 219 biopsy samples before treatment to discover the possibility of using them as an indicator for radiotherapy selection, diagnosis, survival and recurrence. Results: Twenty-two biomarkers (COX2-RT, COX2-NonRT, etc.; 36.67%) had diagnostic value. For survival, four biomarkers (NFKBP65, p130, PINCH and PPAR) were significant in regulating gene promoter activity and overall survival, while four had a trend (AEG1, LOX, SATB1 and SIRT6). Three biomarkers (COX2, PINCH and WRAP53) correlated with disease-free survival, while eight had a trend (AEG1, COX2, Ki67, LOX, NFKBP65, PPAR and SATB1). Four biomarkers (COX2-RT, NFKBP65cyto-RT, P130cyto-NonRT and PPARcyto-RT) were independent prognostic factors for recurrence. NFKBP65 and SIRT6 were significantly correlated with lymph node metastasis regardless of radiation. Patients with high AEG1, LOX, NFKBP65, PPAR and SATB1 had or showed a positive trend for better survival after radiotherapy, while those with positive PINCH and WRAP53 expression would not benefit from radiotherapy. Conclusions: AEG1, LOX, NFKBP65cyto, PPAR and SATB1 could be used as indicators for choosing radiotherapy. COX2-RT, COX2-NonRT and some other biomarkers may provide additional help for diagnosis. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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