Gender-related clinical and management differences in patients with chronic heart failure with reduced ejection fraction.

Autor:	Kocabaş U; Department of Cardiology, Başkent University Istanbul Hospital, Istanbul, Turkey., Kıvrak T; Department of Cardiology, School of Medicine Hospital, Firat University, Elazığ, Turkey., Yılmaz Öztekin GM; Department of Cardiology, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey., Tanık VO; Department of Cardiology, University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey., Özdemir İ; Department of Cardiology, Nizip State Hospital, Gaziantep, Turkey., Kaya E; Department of Cardiology, University of Health Sciences Dr Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Izmir, Turkey., Yüce Eİ; Department of Cardiology, Kelkit State Hospital, Gümüşhane, Turkey., Avcı Demir F; Department of Cardiology, Elmalı State Hospital, Antalya, Turkey., Doğduş M; Department of Cardiology, Karaman State Hospital, Karaman, Turkey., Altınsoy M; Department of Cardiology, University of Health Sciences Ankara Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey., Üstündağ S; Department of Cardiology, Erzincan Binali Yıldırım Unıversıty, Mengücek Gazi Educatıon and Research Hospıtal, Erzincan, Turkey., Özyurtlu F; Department of Cardiology, Grandmedical Hospital, Manisa, Turkey., Karagöz U; Department of Cardiology, Izmir Katip Celebi University Atatürk Education and Research Hospital, Izmir, Turkey., Karakuş A; Department of Cardiology, Besni State Hospital, Adıyaman, Turkey., Urgun OD; Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey., Sinan ÜY; Department of Cardiology, Faculty of Medicine, Institute of Cardiology, Istanbul University, Istanbul, Turkey., Mutlu İ; Department of Cardiology, University of Health Sciences Tepecik Training and Research Hospital, Izmir, Turkey., Şen T; Department of Cardiology, School of Medicine, Kütahya Health Sciences University, Kütahya, Turkey., Astarcıoğlu MA; Department of Cardiology, School of Medicine, Kütahya Health Sciences University, Kütahya, Turkey., Kınık M; Department of Cardiology, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, Turkey., Özden Tok Ö; Department of Cardiology, Memorial Hospital, Istanbul, Turkey., Uygur B; Department of Cardiology, University of Health Sciences Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey., Yeni M; Department of Cardiology, Isparta State Hospital, Isparta, Turkey., Alan B; Department of Cardiology, School of Medicine, Okan University, Istanbul, Turkey., Dalgıç O; Department of Cardiology, Life Park Hospital, Sivas, Turkey., Altay H; Department of Cardiology, Başkent University Istanbul Hospital, Istanbul, Turkey., Pehlivanoğlu S; Department of Cardiology, Başkent University Istanbul Hospital, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	International journal of clinical practice [Int J Clin Pract] 2021 Mar; Vol. 75 (3), pp. e13765. Date of Electronic Publication: 2020 Nov 13.
DOI:	10.1111/ijcp.13765
Abstrakt:	Aim: Gender-related differences have been described in the clinical characteristics and management of patients with chronic heart failure with reduced ejection fraction (HFrEF). However, published data are conflictive in this regard. Methods: We investigated differences in clinical and management variables between male and female patients from the ATA study, a prospective, multicentre, observational study that included 1462 outpatients with chronic HFrEF between January and June 2019. Results: Study population was predominantly male (70.1%). In comparison to men, women with chronic HFrEF were older (66 ± 11 years vs 69 ± 12 years, P < .001), suffered more hospitalisations and presented more frequently with NYHA class III or IV symptoms. Ischaemic heart disease was more frequent in men, whereas anaemia, thyroid disease and depression were more frequent in women. No difference was seen between genders in the use rate of renin-angiotensin system inhibitors, beta-blockers, mineralocorticoid receptor antagonists, or ivabradine, or in the proportion of patients achieving target doses of these drugs. Regarding device therapies, men were more often treated with an implantable cardioverter-defibrillator (ICD) and women received more cardiac resynchronisation therapy. Conclusion: In summary, although management seemed to be equivalent between genders, women tended to present with more symptoms, require hospitalisation more frequently and have different comorbidities than men. These results highlight the importance of gender-related differences in HFrEF and call for further research to clarify the causes of these disparities. Gender-specific recommendations should be included in future guidelines in HFrEF. (© 2020 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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