Impairment of Uterine Contractility Is Associated with Unexplained Infertility.

Autor:	Hunt S; Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.; Monash Health, Clayton, Australia.; Monash IVF, Richmond, Australia., Abdallah KS; Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.; Department of Obstetrics and Gynaecology, Assiut University, Women's Health Hospital, Assiut, Egypt., Ng E; Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong, Hong Kong., Rombauts L; Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.; Monash Health, Clayton, Australia.; Monash IVF, Richmond, Australia., Vollenhoven B; Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.; Monash Health, Clayton, Australia.; Monash IVF, Richmond, Australia., Mol BW; Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.; Monash Health, Clayton, Australia.; Aberdeen Centre for Women's Health Research, University of Aberdeen, Aberdeen, United Kingdom.
Jazyk:	angličtina
Zdroj:	Seminars in reproductive medicine [Semin Reprod Med] 2020 Jan; Vol. 38 (1), pp. 61-73. Date of Electronic Publication: 2020 Oct 14.
DOI:	10.1055/s-0040-1716409
Abstrakt:	The uterine junctional zone represents the juncture between endometrium and myometrium. The junctional zone is hormonally dependent and displays continuous peristaltic activity throughout the menstrual cycle in the nonpregnant state which is concerned with sperm transport and embryo implantation. Peristalsis may be observed using various invasive and noninvasive modalities, of which ultrasound is the most readily applied in the clinical setting. Women with pelvic pathology display alterations in uterine peristalsis which may contribute to infertility. Characterization of peristalsis in infertility subgroups, the development of a subjective peristalsis tool, and the application of potential therapeutics to an assisted reproductive treatment setting are the subject of ongoing investigation. Meta-analysis indicates a potential role for oxytocin antagonist in the improvement of fertility treatments. Competing Interests: B.W.M. is supported by a NHMRC Investigator grant (GNT1176437).B.W.M. reports consultancy for ObsEva, Merck, Merck KGaA, iGenomix, and Guerbet.B.W.M. reports research support by Merck and Guerbet.B.V. is a minority shareholder in Monash IVF Group.L.R. is a minority shareholder in Monash IVF Group.L.R. reports consultancy for Ferring, MSD, and Merck.K.S.A. is on a research scholarship in Monash University funded by the Missions Department of the Egyptian Ministry of Higher Education. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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