The Impact of Asymptomatic Congenital Cytomegalovirus on Adult Quality of Life.

Autor:	Katusic MZ; Department of Developmental Behavioral Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX., Mensah-Bonsu NE; Department of Developmental Behavioral Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX., Miller JA; Department of Pediatric Infectious Disease, Baylor College of Medicine/Texas Children's Hospital, Houston, TX., Turcich MR; Department of Developmental Behavioral Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX., Iovino I; Department of Child Psychology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX., Vinson-Sellers S; Department of Developmental Behavioral Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX., Voigt RG; Department of Developmental Behavioral Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX., Demmler-Harrison GJ; Department of Pediatric Infectious Disease, Baylor College of Medicine/Texas Children's Hospital, Houston, TX.
Jazyk:	angličtina
Zdroj:	Journal of developmental and behavioral pediatrics : JDBP [J Dev Behav Pediatr] 2021 Jan 01; Vol. 42 (1), pp. 46-54.
DOI:	10.1097/DBP.0000000000000843
Abstrakt:	Objective: Children born with asymptomatic congenital cytomegalovirus infection (AcCMV) have increased risk for hearing loss, which may affect their quality of life into adulthood. We aim to determine quality of life outcomes among adults who were identified at birth with AcCMV compared with controls, using the cohort of the Houston Congenital CMV Longitudinal Study. Methods: Quality of life was determined using the self-reported Quality of Life Inventory (QOLI). Sixty-one of 109 AcCMV subjects and 23 of 51 controls completed QOLI. Percentile scores of subjects were compared with percentile scores of controls using Student t tests. QOLI percentile scores were compared among AcCMV subjects with (N = 14) and without hearing loss (N = 47). Results: There was no difference in mean percentile scores on QOLI between AcCMV subjects (59.8 [SD = 27.6]) and controls (57.3 [SD = 35.3]; p = 0.754). Percentile scores indicate an average overall quality of life classification for AcCMV subjects and controls. There was no difference in mean percentile scores on the QOLI between AcCMV subjects with and without hearing loss (54.8 [SD = 25.2]) and 61.3 [SD = 28.3]; p = 0.440, respectively). Conclusion: Adults born with AcCMV do not seem to have lower ratings of quality of life compared with uninfected controls. Although our study had small sample size, hearing loss does not seem to be a significant predictor of QOLI percentile scores among AcCMV subjects. Quality of life in adulthood does not seem to be affected by an individual's awareness of screening positive for CMV, which supports the notion of "no harm" occurring from universal newborn screening for congenital CMV infection. Competing Interests: Disclosure: G. J. Demmler Harrison and J. A. Miller have received funding from Merck Sharp & Dohme Corporation since July 2016 to assist with salary support for data analysis on long-term outcomes of congenital CMV infection. The remaining authors declare no conflict of interest. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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