COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children: A Multinational Study.

Autor:	Antúnez-Montes OY; From the Departamento de Docencia e Investigación. Instituto Latinoamericano de Ecografía en Medicina (ILEM), Ciudad de México, México., Escamilla MI; Fundación Neumológica Colombiana, Bogotá, Colombia., Figueroa-Uribe AF; Hospital Pediátrico Peralvillo, Secretaria de salud, Ciudad de México, México., Arteaga-Menchaca E; Hospital General Regional 200, Instituto Mexicano del Seguro Social, Estado de México, México., Lavariega-Saráchaga M; Grupo Home Health Medical, Ciudad de México, México., Salcedo-Lozada P; Hospital General de Ecatepec Las Américas Estado de México, México., Melchior P; Sao Luiz Hospital, Sao Paulo, Brazil., de Oliveira RB; Sao Luiz Hospital, Sao Paulo, Brazil., Tirado Caballero JC; Plus Mèdica, Lima, Perù., Redondo HP; Hospital Infantil Napoleon Franco Pareja, Cartagena, Colombia., Montes Fontalvo LV; Hospital Infantil Napoleon Franco Pareja, Cartagena, Colombia., Hernandez R; Unidad de Investigacion de Pediatria, Hospital Cayetano Heredia, Lima, Perù., Chavez C; Unidad de Investigacion de Pediatria, Hospital Cayetano Heredia, Lima, Perù., Campos F; Unidad de Infectologia Pediatrica'; Hospital San Bartolomé, Lima, Perù., Uribe F; Unidad de Infectologia Pediatrica'; Hospital San Bartolomé, Lima, Perù., Del Aguila O; Unidad de Infectologia Pediátrica; Hospital Nacional Edgardo Rebagliati Martins. Lima - Perú., Rios Aida JA; Plus Mèdica, Lima, Perù., Buitrago AP; Fundación Neumológica Colombiana, Bogotá, Colombia.; Hospital Pablo Tobón Uribe, Medellín, Colombia., Betancur Londoño LM; Hospital Pablo Tobón Uribe, Medellín, Colombia., Mendoza Vega LF; Jefe servicio de medicina crítica, Hospital Infantil de Tlaxcala, Tlaxcala, Mexico., Hernández CA; Jefatura de pediatria, Hospital general Las Americas, Estado de México, México., Sali M; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy., Higuita Palacio JE; Institution Hospital Universitario de San Vicente Fundacion, Medellin, Colombia., Gomez-Vargas J; Hospital Nacional de Niños ¨Dr. Carlos Sáenz Herrera, San josé, Costa Rica., Yock-Corrales A; Hospital Nacional de Niños ¨Dr. Carlos Sáenz Herrera, San josé, Costa Rica., Buonsenso D; Hospital General de Ecatepec Las Américas Estado de México, México.; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Center for Global Health Research and Studies, Università Cattolica del Sacro Cuore, Roma, Italia.
Jazyk:	angličtina
Zdroj:	The Pediatric infectious disease journal [Pediatr Infect Dis J] 2021 Jan; Vol. 40 (1), pp. e1-e6.
DOI:	10.1097/INF.0000000000002949
Abstrakt:	Background: To date, there are no comprehensive data on pediatric COVID-19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Latin American children, to appropriately plan and allocate resources to face the pandemic on a local and international level. Methods: Ambispective multicenter cohort study from 5 Latin American countries. Children 18 years of age or younger with microbiologically confirmed SARS-CoV-2 infection or fulfilling MIS-C definition were included. Findings: Four hundred nine children were included, with a median age of 3.0 years (interquartile range 0.6-9.0). Of these, 95 (23.2%) were diagnosed with MIS-C. One hundred ninety-one (46.7%) children were admitted to hospital and 52 (12.7%) required admission to a pediatric intensive care unit. Ninety-two (22.5%) patients required oxygen support: 8 (2%) were started on continuous positive airway pressure and 29 (7%) on mechanical ventilation. Thirty-five (8.5%) patients required inotropic support. The following factors were associated with pediatric intensive care unit admission: preexisting medical condition (P < 0.0001), immunodeficiency (P = 0.01), lower respiratory tract infection (P < 0.0001), gastrointestinal symptoms (P = 0.006), radiologic changes suggestive of pneumonia and acute respiratory distress syndrome (P < 0.0001) and low socioeconomic conditions (P = 0.009). Conclusions: This study shows a generally more severe form of COVID-19 and a high number of MIS-C in Latin American children, compared with studies from China, Europe and North America, and support current evidence of a more severe disease in Latin/Hispanic children or in people of lower socioeconomic level. The findings highlight an urgent need for more data on COVID-19 in Latin America.
Databáze:	MEDLINE
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