Elaeocarpus floribundus Bl. seeds as a new source of bioactive compounds with promising antioxidant and antimicrobial properties.

Autor:	Ogundele AV; Natural Products Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Department of Chemistry, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria., Haldar S; Medicinal, Aromatic and Economic Plants Group, Biological Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, India., Yadav A; Biotechnology Group, Biological Science and Technology Division, CSIR- North East Institute of Science and Technology, Jorhat, India., Das AM; Natural Products Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Jazyk:	angličtina
Zdroj:	Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2020 Oct 15; Vol. 76 (3-4), pp. 141-146. Date of Electronic Publication: 2020 Oct 15 (Print Publication: 2021).
DOI:	10.1515/znc-2020-0114
Abstrakt:	The fruits of Elaeocarpus floribundus Bl. (Elaeocarpaceae) are edible and are normally prescribed for treatment of diseases. The medicinal uses of the fruit create considerable quantities of seeds as wastes. In an attempt to valorise this biomass, we studied the antimicrobial and antioxidant activities of the ethanolic seed extract. The extract inhibited the growth of the tested pathogens and was also a very strong scavenger of DPPH free radicals. Consequently, the extract was phytochemically investigated and this study reports the initial isolation of five phenolic compounds from this source. The structures of the isolated compounds were elucidated by spectra analyses including HR-ESI-MS, 1D and 2D NMR experiments. The isolated compounds exhibited a wide range of antimicrobial activities against the tested pathogens. Gallic acid ( 4 ) showed the most activity against Bacillus subtilis with a minimum inhibitory concentration (MIC) value of 30 µg/mL, while the MIC values of the antimicrobial standards range between 10 and 35 µg/mL. Compound 4 , crude ethanolic extract, and the ethyl acetate fraction were more a potent free radical scavenger of DPPH compared to ascorbic acid. Hence, the seeds of E. floribundus could be considered as a new source of bioactive compounds for pharmaceutical and food-related industries. (© 2020 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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