Sweet Syndrome in an Elderly Man With Well-Controlled Human Immunodeficiency Virus.

Autor:	Mudroch SM; Department of Medicine, Wright-Patterson Medical Center, Wright-Patterson Air Force Base, USA.; Department of Medicine, Wright State University, Dayton, USA., Rohan C; Department of Dermatology, Wright-Patterson Medical Center, Wright-Patterson Air Force Base, USA.; Department of Medicine, Wright State University, Dayton, USA.; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA., Conger NG; Department of Infectious Diseases, Wright-Patterson Medical Center, Wright-Patterson Air Force Base, USA.; Department of Medicine, Wright State University, Dayton, USA.; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA., Lindholm DA; Department of Infectious Diseases, Wright-Patterson Medical Center, Wright-Patterson Air Force Base, USA.; Department of Medicine, Wright State University, Dayton, USA.; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2020 Sep 09; Vol. 12 (9), pp. e10330. Date of Electronic Publication: 2020 Sep 09.
DOI:	10.7759/cureus.10330
Abstrakt:	Acute febrile neutrophilic dermatosis, or Sweet syndrome, is a rare disorder associated with medications, underlying malignancy, or systemic inflammatory conditions. We present the case of a 71-year-old male living with well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy, who presented with multiple painful, pseudo-vesicular, almost-necrotic appearing papules on his bilateral palms in the setting of constitutional symptoms and altered mental status. Biopsy of his palmar lesions revealed a dense, diffuse, dermal neutrophilic infiltrate consistent with Sweet syndrome. Infectious, rheumatologic, and oncologic work-up was negative. He was treated initially with intravenous immunoglobulin, prednisone, and dapsone; and he was continued on suppressive dapsone. He responded well clinically, but he relapsed multiple times in the setting of medication non-adherence before his ultimate diagnosis with sarcoidosis. A review of the literature of persons living with HIV and diagnosed with Sweet syndrome reveals no clear clinical association between the two despite plausible pathologic mechanisms. Patients living with HIV who are diagnosed with Sweet syndrome should be evaluated thoroughly for potential etiologies; the search for the underlying etiology of Sweet syndrome should go beyond their diagnosis of HIV. Competing Interests: Copyright statement: Some authors are employees of the U.S. Government. This work was prepared as part of their official duties. Title 17 U.S.C. 105 provides that ‘Copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. 101 defines a United States Government work as a work prepared by a military service member or employee of the United States Government as part of that person’s official duties. Disclaimer: The contents of this publication are the sole responsibility of the author(s) and do not necessarily reflect the views, opinions, or policies of Uniformed Services University of the Health Sciences (USUHS), the Department of Defense (DoD), the Departments of the Air Force, or Wright-Patterson Medical Center. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. Government. (Copyright © 2020, Mudroch et al.)
Databáze:	MEDLINE
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