[OvoL factors: a family of key regulators of epithelium mesenchyme plasticity and stem cells].

Autor:	Mancheno-Ferris A; Centre de Biologie du Développement, Université Paul Sabatier Toulouse III, Bâtiment 4R3, 118 route de Narbonne, 31062 Toulouse, France. - CNRS, UMR5547, Centre de Biologie du Développement, Toulouse, France., Polesello C; Centre de Biologie du Développement, Université Paul Sabatier Toulouse III, Bâtiment 4R3, 118 route de Narbonne, 31062 Toulouse, France. - CNRS, UMR5547, Centre de Biologie du Développement, Toulouse, France., Payre F; Centre de Biologie du Développement, Université Paul Sabatier Toulouse III, Bâtiment 4R3, 118 route de Narbonne, 31062 Toulouse, France. - CNRS, UMR5547, Centre de Biologie du Développement, Toulouse, France.
Jazyk:	francouzština
Zdroj:	Medecine sciences : M/S [Med Sci (Paris)] 2020 Oct; Vol. 36 Hors série n° 1, pp. 61-66. Date of Electronic Publication: 2020 Oct 14.
DOI:	10.1051/medsci/2020193
Abstrakt:	Most prevalent cancers are of epithelial origin and their morbidity often results from secondary tumors. Cancer aggressiveness relates to intratumoral heterogeneity, including rare tumor initiating cells that share many features with adult stem cells. Both normal and cancer stem cells are characterized by their plasticity between epithelial and mesenchymal phenotypes, progressing through a series of reversible intermediates. While a core of regulators (Snail, Zeb1-2,...) is renowned to promote epithelial to mesenchyme transition (EMT), OvoL/Shavenbaby factors now emerge as a family of key epithelial stabilizers. Therefore, pro-EMT and OvoL/Shavenbaby transcription factors could provide a molecular rheostat to control stemness and epithelial-mesenchyme plasticity. We address this question in flies, in which the unique OvoL/Shavenbaby factor offers a powerful in vivo paradigm for functional analyses. Our results show that Shavenbaby is critical for adult stem cell homeostasis, and directly interacts with the Hippo pathway to protect stem cells from death. (© 2020 médecine/sciences – Inserm.)
Databáze:	MEDLINE
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