Intestinal SALSA/dmbt1 levels are decreased in prematurely born infants.

Autor: Reichhardt MP; Department of Bacteriology and Immunology and Translational Immunology Research Program, University of Helsinki, Helsinki, Finland., Messing M; Department of Bacteriology and Immunology and Translational Immunology Research Program, University of Helsinki, Helsinki, Finland., Andersson S; Department of Pediatrics and Children's Hospital, University of Helsinki, Helsinki, Finland., Kolho KL; Department of Pediatrics and Children's Hospital, University of Helsinki, Helsinki, Finland.; Faculty of Medicine and HealthTechnology, Tampere University, Tampere, Finland., Meri S; Department of Bacteriology and Immunology and Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Scandinavian journal of immunology [Scand J Immunol] 2021 Feb; Vol. 93 (2), pp. e12987. Date of Electronic Publication: 2020 Nov 05.
DOI: 10.1111/sji.12987
Abstrakt: The first months of life represent a crucial time period for an infant. Alongside establishing the early microbiome, the mucosal immunological homeostasis is being developed. Both processes may be perturbed in prematurely born infants. The glycoprotein SALSA plays a role in mucosal inflammation and microbial clearance. It is one of the most abundant molecules on the intestinal mucosal surfaces in early life. SALSA binds to many types of microbes and host defence molecules like IgA, C1q and collectin molecules. We here describe the development in faecal SALSA levels during the first three months of life. During these 90 days, the median SALSA level in full-term babies decreased from 1100 μg/mL (range 49-17 000 μg/mL) to 450 μg/mL (range 33-1000 μg/mL). Lower levels of SALSA were observed in prematurely born infants in the same time period. Our novel observation thus indicates an impact of prematurity on an important component of the infant intestinal immune system. Changes in SALSA in early life may have an effect on the early establishment of the human microbiome.
(© 2020 The Scandinavian Foundation for Immunology.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje