Nanofibrous cosmetic face mask for transdermal delivery of nano gold: synthesis, characterization, release and zebra fish employed toxicity studies.

Autor:	Manatunga DC; Centre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka., Godakanda VU; Centre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka., Herath HMLPB; Centre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka., de Silva RM; Centre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka., Yeh CY; Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan., Chen JY; Research Centre for Sustainable Energy and Nanotechnology (RCSEN), National Chung Hsing University, Taichung 402, Taiwan., Akshitha de Silva AA; Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan., Rajapaksha S; Department of Engineering Technology, Faculty of Technology, University of Sri Jayawardenapura, Sri Lanka., Nilmini R; Department of Engineering Technology, Faculty of Technology, University of Sri Jayawardenapura, Sri Lanka., Nalin de Silva KM; Centre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka.
Jazyk:	angličtina
Zdroj:	Royal Society open science [R Soc Open Sci] 2020 Sep 30; Vol. 7 (9), pp. 201266. Date of Electronic Publication: 2020 Sep 30 (Print Publication: 2020).
DOI:	10.1098/rsos.201266
Abstrakt:	This study involves the generation of gold nanoparticles (Au NPs) via a novel natural/non-toxic methodology using tea and orange-peel extracts. These were then embedded into a novel blend composed of a polyethylene oxide and gelatin (PEO-Gel) fibre mat. The scanning electron microscopy results indicated that the addition of both collagen (COL) and ascorbic acid (AA) into the PEO-Gel system (PEO-Gel-AA-COL system) enhances the Au NP incorporation into nanofibres leading to a diameter of 164.60 ± 20.95 and 192.43 ± 39.14 nm in contrast to the spraying observed with the Au PEO-Gel system alone. Releasing studies conducted over 30 min indicated that the PEO-Gel-AA-COL-orange peel Au (OpAu) system accounts for a higher content of Au release than the green tea Au (GtAu) NP system where a maximum release could be attained within 10-30 min depending on the amount of Au NPs that have been incorporated. Moreover, the transdermal diffusion studies conducted using Strat membrane indicated that Au NPs from both formulations (PEO-Gel-AA-COL-GtAu nanofibre, PEO-Gel-AA-COL-OpAu nanofibre) have diffused through the stratum corneum and trapped in the dermis and epidermis indicating its transdermal deliverability. Additionally, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay revealed that nanofibres have similar radical scavenging activity like AA standard. Toxicity evaluation on a zebra fish embryo model confirmed that both GtAu NPs and OpAu NPs do not induce any teratogenic activity and are safe to be used in the range of 1.0-167 µg ml -1 . Competing Interests: Authors have no competing interests. (© 2020 The Authors.)
Databáze:	MEDLINE
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