Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia.

Autor:	Battaglini D; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy.; University of Barcelona, Barcelona, Spain., Motos A; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; University of Barcelona, Barcelona, Spain., Li Bassi G; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; University of Barcelona, Barcelona, Spain.; BITRECS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Yang H; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Pagliara F; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy., Yang M; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; University of Barcelona, Barcelona, Spain., Aguilera Xiol E; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; University of Barcelona, Barcelona, Spain., Meli A; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; University of Milan, Milan, Italy., Bobi J; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Frigola G; Departamento de Anatomía Patológica, Hospital Clínic de Barcelona, Barcelona, Spain., Senussi T; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy., Idone F; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Travierso C; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; University of Milan, Milan, Italy., Chiurazzi C; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy., Fernandez-Barat L; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; University of Barcelona, Barcelona, Spain., Rigol M; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Ramirez J; Departamento de Anatomía Patológica, Hospital Clínic de Barcelona, Barcelona, Spain., Pelosi P; Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy., Chiumello D; University of Milan, Milan, Italy., Antonelli M; Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA., Bringue J; Department of Intensive Care Medicine, CIBER Enfermedades Respiratorias, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain., Artigas A; Department of Intensive Care Medicine, CIBER Enfermedades Respiratorias, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain., Guerrero L; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain.; Division of Medicines, Pharmacy Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Soy D; Division of Medicines, Pharmacy Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Torres A; Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain atorres@clinic.cat.; Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; University of Barcelona, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Dec 16; Vol. 65 (1). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
DOI:	10.1128/AAC.01009-20
Abstrakt:	Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezolid in a porcine model of severe MRSA pneumonia. In 18 mechanically ventilated pigs (32.11 ± 1.18 kg), 75 ml of 10 6 CFU/ml of MRSA was administered into each pulmonary lobe. After the onset of pneumonia, pigs were randomized into three groups: a control group, a group receiving 22.5 mg/kg of body weight every 24 h (q24h) of telavancin, and a group receiving 10 mg/kg q12h of linezolid intravenously. Tracheal aspirate and bronchoalveolar lavage (BAL) fluids were cultured every 24 h. After 48 h of treatment, tissue samples were collected from the ventral and dorsal sections of each lobe. Microbiological and histopathological analyses were performed. Lung tissue concentrations differed among the groups ( P  = 0.019), with the lowest MRSA lung burden in the telavancin group ( P  < 0.05 versus the control). MRSA was detected in 46.7%, 40.0%, and 21.7% of the lung tissue samples from the control, linezolid, and telavancin groups, respectively ( P  < 0.001). MRSA concentrations differed among the groups in tracheal aspirate fluid ( P  = 0.011) but not in BAL fluid. Furthermore, there was no increased risk of kidney injury during telavancin use. Thus, telavancin has higher bactericidal efficacy than linezolid during the first 48 h of treatment in a porcine model of severe MRSA pneumonia. However, studies are needed to confirm the benefits of telavancin in treating MRSA nosocomial pneumonia. (Copyright © 2020 American Society for Microbiology.)
Databáze:	MEDLINE
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