Prediction of pathological complete response after neoadjuvant chemotherapy in breast cancer by combining magnetic resonance imaging and core needle biopsy.

Autor: Narui K; Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Japan., Ishikawa T; Department of Breast Oncology and Surgery, Tokyo Medical University, Tokyo, Japan. Electronic address: tishik55@gmail.com., Oba MS; Department of Medical Statistics, Toho University, Tokyo, Japan., Hasegawa Y; Department of Breast Surgery, Hirosaki Municipal Hospital, Hirosaki, Japan., Kaise H; Department of Breast Oncology and Surgery, Tokyo Medical University, Tokyo, Japan., Kawate T; Department of Breast Oncology and Surgery, Tokyo Medical University, Tokyo, Japan., Yamada A; Department of Gastroenterological Surgery, Yokohama City University, Yokohama, Japan., Yamada K; Department of Breast Oncology and Surgery, Tokyo Medical University, Tokyo, Japan., Suzuki Y; Department of Breast and Endocrine Surgery, Tokai University School of Medicine, Isehara, Japan., Niikura N; Department of Breast and Endocrine Surgery, Tokai University School of Medicine, Isehara, Japan., Kohno N; Department of Breast Surgery, Kobe Kaisei Hospital, Kobe, Japan., Kimoto T; Department of Breast Surgery, Kobe Kaisei Hospital, Kobe, Japan., Sugae S; Department of Gastroenterological Surgery, Yokohama City University, Yokohama, Japan., Kosaka Y; Department of Breast and Endocrine Surgery, Kitasato University School of Medicine, Sagamihara, Japan., Miyashita M; Department of Surgery, Konan Hospital, Kobe, Japan., Okamura T; Department of Breast and Endocrine Surgery, Tokai University School of Medicine, Isehara, Japan., Shimizu D; Department of Breast Surgery, Yokohama City Minato Red Cross Hospital, Yokohama, Japan., Tanino H; Department of Breast and Endocrine Surgery, Kitasato University School of Medicine, Sagamihara, Japan., Tanabe M; Division of Diagnostic Pathology, Yokohama City University Medical Center, Yokohama, Japan., Morita S; Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan., Endo I; Department of Gastroenterological Surgery, Yokohama City University, Yokohama, Japan., Tokuda Y; Department of Breast and Endocrine Surgery, Tokai University School of Medicine, Isehara, Japan.
Jazyk: angličtina
Zdroj: Surgical oncology [Surg Oncol] 2020 Dec; Vol. 35, pp. 447-452. Date of Electronic Publication: 2020 Oct 06.
DOI: 10.1016/j.suronc.2020.10.002
Abstrakt: Background: Pathological complete response (pCR) is often achieved by neoadjuvant chemotherapy (NAC), particularly in hormone receptor-negative breast cancer. Contrast-enhanced magnetic resonance imaging (cMRI) is the most reliable imaging modality to evaluate the pathological effect of NAC. Ultrasonography is indispensable to collect representative specimens from the target lesion by core needle biopsy (CNB). This study aimed to evaluate the accuracy of predicting pCR by adding CNB after NAC, in cases with complete clinical response (cCR) diagnosed by cMRI.
Methods: In this prospective multicentre study, we evaluated patients diagnosed with cCR by cMRI after NAC. Ultrasound-guided CNB (uCNB) using a 14G needle was performed without clip markers under general anaesthesia as planned surgery. Specimens collected by uCNB were compared to those resected surgically and were categorized as (i) no carcinoma (ypT0), (ii) no invasive carcinoma and only residual carcinoma in situ (ypTis) and (iii) residual invasive carcinoma. The concordance of pathological results between the uCNB and surgical specimens was evaluated.
Results: Of the 83 patients evaluated, 41 (49.4%) and 17 (20.5%) of them had ypT0 and ypTis, respectively. The false negative rates (FNR), sensitivity and specificity for predicting ypT0 by uCNB were 50.0%, 50.0%, 100%, respectively, and those for predicting ypT0+ypTis were 28.0%, 72.0% and 98.3%, respectively. The concordance rates were 74.7% (62/83) for ypT0 and 90.4% (75/83) for ypT0+ypTis.
Conclusion: In cCR cases diagnosed by cMRI, uCNB was not accurate enough to predict pCR. Additional modalities like clip placements and/or thicker core needles may be required for better prediction.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: