Serum level of interleukin-22 in patients with cutaneous warts: A case-control study.
| Autor: | Marie REM; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Abuzeid AQEM; Department of Dermatology, Ministry of Health and Population, El- Tur General Hospital, South Sinai, Egypt., Attia FM; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Anani MM; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Gomaa AHA; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Atef LM; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cosmetic dermatology [J Cosmet Dermatol] 2021 Jun; Vol. 20 (6), pp. 1782-1787. Date of Electronic Publication: 2020 Oct 24. |
| DOI: | 10.1111/jocd.13779 |
| Abstrakt: | Background: Warts are viral cutaneous infections caused by human papilloma virus (HPV), presented by verrucous growth over the skin surface. The immune response is considered to play a crucial role in HPV clearance. It depends on intact cellular immunity including natural killer (NK) cell and cytotoxic T cells. It has been clarified that T-helper (Th) 1 cytokines (interleukin (IL)-2, interferon-γ, and tumor necrosis factor-a) and IL-17 are involved in HPV clearance. IL-22 is one of IL-10 family of cytokines produced by NK cells, Th1, Th17, and Th22 cells. In the skin, IL-22 reduces keratinocyte cornification and enhances keratinocyte production of antimicrobial peptides. IL-22 overexpression has been demonstrated in various viral infections and skin inflammatory disorders. Aim: The aim of this study was to assess serum levels of IL-22 in patients with warts and its association with their different clinical characteristics. Methods: The study included 20 patients with warts and 20 control subjects. Serum concentration of IL-22 was measured by enzyme-linked immune sorbent assay. Results: Serum levels of IL-22 were significantly higher in patients with warts than in control subjects (P < .001). The levels were significantly higher in patients with recurrent warts after prior treatment than in patients with first-time warts (P = .007). Moreover, a significant positive correlation was detected between serum levels of IL-22 and the number of warts (P = .017). Conclusion: Serum level of IL-22 was elevated in patients with warts. Thus, IL-22 may have a crucial role in the antiviral immune response against this infection. (© 2020 Wiley Periodicals LLC.) |
| Databáze: | MEDLINE |
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