Piceatannol mediated regulation of deregulated signaling pathways in different cancers: Tumbling of the ninepins of molecular oncology.

Autor:	Nayyab S; Department of Biotechnology, Faculty of Science, University of Sialkot, Sialkot, Pakistan., Naureen H; Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan., Maryam A; Forman Christian College University, Lahore, Pakistan., Attar R; Department of Obstetrics and Gynecology, Yeditepe University, İstanbul 34755, Turkey., Sabitaliyevich UY; Department of Health Policy and Health Care Development, Kazakh Medical University of Continuing Education, Almaty 050004, Kazakhstan., Konysbayevna KK; Ministry of Health of the Republic of Kazakhstan. Zhibek zholy 5, Almaty, Kazakhstan., Farooqi AA; Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
Jazyk:	angličtina
Zdroj:	Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2020 Sep 30; Vol. 66 (6), pp. 157-163. Date of Electronic Publication: 2020 Sep 30.
Abstrakt:	With the recent technological advancements, a new golden era of natural products drug discovery has dawned. Increasingly it is being realized that structural modularity of many pharmacologically active products derived natural sources allows a building-block approach which can be exploited for analysis of regulation of deregulated oncogenic protein networks in different cancers. Piceatannol has been shown to effectively modulate JAK/STAT, Wnt/β-catenin, mTOR pathway in different cancers. In addition, certain hints have emerged which shed light on the regulation of microRNAs by piceatannol in some cancers. Regulation of deregulated oncogenic pathways by Piceatannol is gradually capturing attention and might be helpful in the multi-targeting of deregulated oncogenic networks in cancers.
Databáze:	MEDLINE
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