Visceral Adiposity and Glucoregulatory Peptides are Associated with Susceptibility to Type 2 Diabetes: The TOFI_Asia Study.

Autor: Sequeira IR; Human Nutrition Unit, School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand.; High Value Nutrition, National Science Challenge, New Zealand., Yip W; Human Nutrition Unit, School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand.; High Value Nutrition, National Science Challenge, New Zealand., Lu L; Human Nutrition Unit, School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand.; High Value Nutrition, National Science Challenge, New Zealand., Jiang Y; Department of Statistics, Faculty of Science, University of Auckland, Auckland, New Zealand., Murphy R; High Value Nutrition, National Science Challenge, New Zealand.; Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Auckland District Health Board, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand., Plank L; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Zhang S; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.; School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand., Liu H; School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand., Chuang CL; School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand., Vazhoor-Amarsingh G; School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand., Cooper G; High Value Nutrition, National Science Challenge, New Zealand.; Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.; School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand.; Centre for Advanced Discovery and Experimental Therapeutics, Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Department of Pharmacology, Division of Medical Sciences, University of Oxford, Oxford, UK., Poppitt S; Human Nutrition Unit, School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand.; High Value Nutrition, National Science Challenge, New Zealand.; Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand.; Riddet Centre of Research Excellence for Food and Nutrition, Palmerston North, New Zealand.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2020 Dec; Vol. 28 (12), pp. 2368-2378. Date of Electronic Publication: 2020 Oct 10.
DOI: 10.1002/oby.22994
Abstrakt: Objective: Ethnic differences in fat deposition contribute to type 2 diabetes (T2D). Identification of biomarkers that underpin dysglycemia are needed for better-targeted prevention and treatment.
Methods: The cross-sectional thin-on-the-outside-fat-on-the-inside (TOFI)_Asia study investigated adipose depots and clinical biomarkers as predictors of fasting plasma glucose (FPG) and insulin resistance (IR; assessed using the updated homeostatic model assessment of IR) in lean and overweight normo- and dysglycemic Chinese (n = 199) and Caucasian (n = 158) individuals. Multivariate least-angle regression models were used to identify predictors of FPG and IR.
Results: At similar age and BMI, Chinese individuals had lower body weight but had a greater percentage of total abdominal adipose tissue and a greater percentage of total visceral adipose tissue (VAT) (all P < 0.005). In Chinese individuals, FPG, hemoglobin A 1c , fasting insulin, and triglycerides were higher, whereas HDL cholesterol and total and high-molecular-weight adiponectin levels were lower (all P < 0.0001). Raised liver enzyme and peptide concentrations (P < 0.02) were consistent with increased T2D risk. Lean Chinese women (<25 kg/m 2 ) had greater total abdominal adipose tissue (kilograms) and VAT (kilograms) than Caucasian women, exhibiting the TOFI profile, with raised FPG (P < 0.001) and IR (P = 0.01). Risk factors for elevated FPG specific to Chinese individuals included male gender, VAT, and triglycerides (R 2  = 0.33), and risk factors for IR specific to Chinese individuals included amylin, C-peptide, and glucagon (R 2  = 0.49). VAT, amylin, and C-peptide were predictors in Caucasian individuals.
Conclusions: VAT contributed to dysglycemia in both ethnicities, particularly in Chinese individuals characterized by the TOFI phenotype, as did the glucoregulatory peptides amylin and C-peptide, providing targets for T2D prevention.
(© 2020 The Obesity Society.)
Databáze: MEDLINE
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