Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.
Autor: | Moore EE; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.; Medical Scientist Training Program, School of Medicine, Vanderbilt University, Nashville, TN, USA., Liu D; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Bown CW; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA., Kresge HA; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA., Gupta DK; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pechman KR; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Mendes LA; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Davis LT; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Gifford KA; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Anderson AW; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Wang TJ; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Landman BA; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA., Hohman TJ; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Jefferson AL; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA. angela.jefferson@vumc.org.; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. angela.jefferson@vumc.org.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. angela.jefferson@vumc.org. |
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Jazyk: | angličtina |
Zdroj: | Brain imaging and behavior [Brain Imaging Behav] 2021 Aug; Vol. 15 (4), pp. 2040-2050. Date of Electronic Publication: 2020 Oct 10. |
DOI: | 10.1007/s11682-020-00398-0 |
Abstrakt: | Subclinical cardiac dysfunction is associated with smaller total brain volume on magnetic resonance imaging (MRI). To study whether cardiac output relates to regional measurements of grey and white matter structure, older adults (n = 326) underwent echocardiogram to quantify cardiac output (L/min) and brain MRI. Linear regressions related cardiac output to grey matter volumes measured on T (© 2020. Springer Science+Business Media, LLC, part of Springer Nature.) |
Databáze: | MEDLINE |
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