Dietary glycemic index, glycemic load, and lung cancer risk: A case-control study in Los Angeles County.

Autor: Chang CP; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, United States; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, United States., Meyers TJ; Department of Epidemiology and Biostatistics, University of California, San Francisco (UCSF), San Francisco, CA, United States., Fu A; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, United States., Zhang MY; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, United States., Tashkin DP; Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States., Rao JY; Department of Pathology, Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, United States., Cozen W; Departments of Preventive Medicine and Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States., Mack TM; Departments of Preventive Medicine and Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States., Hashibe M; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, United States., Morgenstern H; Departments of Epidemiology and Environmental Health Sciences, School of Public Health and Department of Urology, Medical School, University of Michigan, Ann Arbor, MI, United States., Zhang ZF; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, United States. Electronic address: zfzhang@ucla.edu.
Jazyk: angličtina
Zdroj: Cancer epidemiology [Cancer Epidemiol] 2020 Dec; Vol. 69, pp. 101824. Date of Electronic Publication: 2020 Oct 08.
DOI: 10.1016/j.canep.2020.101824
Abstrakt: Background: Although there is some evidence of positive associations between both the glycemic index (GI) and glycemic load (GL) with cancer risk, the relationships with lung cancer risk remain largely unexplored. We evaluated the associations between GI and GL with lung cancer.
Methods: The analyses were performed using data from a population-based case-control study recruited between 1999 and 2004 in Los Angeles County. Dietary factors were collected from 593 incident lung cancer cases and 1026 controls using a modified food frequency questionnaire. GI and GL were estimated using a food composition table. Adjusted odds ratios (ORs) and 95 % confidence intervals (CI) were estimated using unconditional logistic regression adjusting for potential confounders.
Results: Dietary GI was positively associated with lung cancer (OR for upper vs. lower tertile = 1.62; 95 % CI: 1.17, 2.25). For histologic subtypes, positive associations were observed between GI and adenocarcinoma (OR for upper vs. lower tertile = 1.82; 95 % CI: 1.22, 2.70) and small cell carcinoma (OR for upper vs. lower tertile = 2.68; 95 % CI: 1.25, 5.74). No clear association between GL and lung cancer was observed.
Conclusion: These findings suggest that high dietary GI was associated with increased lung cancer risk, and the positive associations were observed for both lung adenocarcinoma and small cell lung carcinoma. Replication in an independent dataset is merited for a broader interpretation of our results.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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