Corneal development: Role of the periocular mesenchyme and bi-directional signaling.

Autor: Walker H; McMaster University, Health Sciences Centre, 1280 Main St. W., L8S 4L8, Hamilton, ON, Canada., Akula M; McMaster University, Health Sciences Centre, 1280 Main St. W., L8S 4L8, Hamilton, ON, Canada., West-Mays JA; McMaster University, Health Sciences Centre, 1280 Main St. W., L8S 4L8, Hamilton, ON, Canada. Electronic address: westmayj@mcmaster.ca.
Jazyk: angličtina
Zdroj: Experimental eye research [Exp Eye Res] 2020 Dec; Vol. 201, pp. 108231. Date of Electronic Publication: 2020 Oct 09.
DOI: 10.1016/j.exer.2020.108231
Abstrakt: The cornea is a highly specialized transparent tissue located at the anterior most surface of the eye. It consists of three main layers, the outer stratified squamous epithelium, the inner endothelium, and the intermediate stroma. Formation of these layers during development involves a complex interaction between ectodermal-derived structures, such as the overlying head ectoderm with the periocular mesenchyme (POM), the latter of which is comprised of neural crest cells (NCC) and mesoderm-derived progenitor cells. Regulation of corneal epithelial development, including both epithelial cell fate and stratification, has been shown to depend on numerous bi-directional mesenchymal-epithelial signaling pathways. In this review we pay particular attention to the genes and signaling pathways that involve the POM.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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