Serum osteocalcin is associated with subjective stress in people with depression and type 2 diabetes.

Autor: Nguyen MM; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle Room 4207, Toronto, Ontario, M5S 1A8, Canada; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada., Anita NZ; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle Room 4207, Toronto, Ontario, M5S 1A8, Canada; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada., Darwish L; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle Room 4207, Toronto, Ontario, M5S 1A8, Canada; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada., Major-Orfao C; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada., Colby-Milley J; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada., Wong SK; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle Room 4207, Toronto, Ontario, M5S 1A8, Canada; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada., Sugamori KS; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle Room 4207, Toronto, Ontario, M5S 1A8, Canada., Lanctôt KL; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle Room 4207, Toronto, Ontario, M5S 1A8, Canada; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada; Department of Psychiatry University of Toronto, 250 College Street 8th floor, Toronto, Ontario, M5T 1R8, Canada., Herrmann N; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Department of Psychiatry University of Toronto, 250 College Street 8th floor, Toronto, Ontario, M5T 1R8, Canada; Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada., Oh PI; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada., Yang P; Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada., Shah BR; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada., Gilbert J; Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada., Assal A; Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada., Halperin IJ; Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada., Mitchell J; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle Room 4207, Toronto, Ontario, M5S 1A8, Canada., Swardfager W; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle Room 4207, Toronto, Ontario, M5S 1A8, Canada; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada; Cardiovascular Prevention and Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, 347 Rumsey Rd, East York, Ontario, M4G 2V6, Canada; Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada. Electronic address: w.swardfager@utoronto.ca.
Jazyk: angličtina
Zdroj: Psychoneuroendocrinology [Psychoneuroendocrinology] 2020 Dec; Vol. 122, pp. 104878. Date of Electronic Publication: 2020 Sep 23.
DOI: 10.1016/j.psyneuen.2020.104878
Abstrakt: Background: Low serum osteocalcin is a risk factor for type 2 diabetes mellitus (T2DM), and osteocalcin release from bone is associated with an acute stress response in mice. Both diabetes and stress are associated with depression. Here, we assess relationships between serum osteocalcin, depression and subjective stress in people with T2DM.
Methods: Participants with T2DM (HbA1c above 6.4 %, impaired fasting glucose or impaired glucose tolerance) were assessed for a major depressive episode using the research version of the Structured Clinical Interview for DSM-5 depression criteria (SCID-5RV). Subjective stress over the past month was assessed using the Perceived Stress Scale (PSS). Serum carboxylated (cOCN) and fully decarboxylated (dcOCN) osteocalcin were assayed from fasting morning blood by commercial enzyme-linked immunosorbent assay.
Results: Among 95 participants (mean age 62.4 ± 9.9, 51 % women), 22 % were experiencing a depressive episode (9 men, 12 women). The presence of a depressive episode was not associated with dcOCN or cOCN concentrations; however, higher concentrations of cOCN were associated with higher PSS scores in participants with depression (r = 0.585, p = 0.005). In an analysis of covariance model controlling for age, sex, body mass index, glycemic control (glycosylated hemoglobin), insulin resistance (homeostatic model), depression, and antidepressant use, cOCN was associated with PSS scores (F=10.302, p = 0.002), and this relationship was stronger in those with depression (depression × cOCN interaction F=4.978, p = 0.028). Although associations between dcOCN concentrations and PSS scores did not reach significance, the same trend seen with cOCN concentrations was observed in participants with depression for dcOCN (r=0.365, p=0.10), and for a depression × dcOCN interaction associated with PSS scores in the whole group (F=2.165, p = 0.15).
Conclusions: Osteocalcin is a neuroendocrine marker associated with perceived chronic stress among people with T2DM experiencing a depressive episode.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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