Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review.

Autor: Adhikari B; Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal., Marasini BP; Department of Biotechnology, National College, Tribhuvan University, Kirtipur, Nepal., Rayamajhee B; School of Optometry and Vision Science, Faculty of Science, University of New South Wales (UNSW), Sydney, Australia.; Department of Infection and Immunology, Kathmandu Research Institute for Biological Sciences (KRIBS), Lalitpur, Nepal., Bhattarai BR; Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal., Lamichhane G; Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal., Khadayat K; Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.; Department of Biotechnology, National College, Tribhuvan University, Kirtipur, Nepal., Adhikari A; Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal., Khanal S; Department of Biotechnology, National College, Tribhuvan University, Kirtipur, Nepal., Parajuli N; Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2021 Mar; Vol. 35 (3), pp. 1298-1312. Date of Electronic Publication: 2020 Oct 09.
DOI: 10.1002/ptr.6893
Abstrakt: The whole world is entangled by the coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), people are dying in thousands each day, and without an actual medication, it seems not possible for the bringing this global health crisis to a stop. Natural products have been in constant use since ancient times and are proven by time to be effective. Crude extract or pure compounds isolated from medicinal plants and/or herbs such as Artemisia annua, Agastache rugosa, Astragalus membranaceus, Cassia alata, Ecklonia cava, Gymnema sylvestre, Glycyrrhizae uralensis, Houttuynia cordata, Lindera aggregata, Lycoris radiata, Mollugo cerviana, Polygonum multiflorum, Pyrrosia lingua, Saposhnikoviae divaricate, Tinospora cordifolia etc. have shown promising inhibitory effect against coronavirus. Several molecules, including acacetin, amentoflavone, allicin, blancoxanthone, curcumin, daidzein, diosmin, epigallocatechin-gallate, emodin, hesperidin, herbacetin, hirsutenone, iguesterin, jubanine G, kaempferol, lycorine, pectolinarin, phloroeckol, silvestrol, tanshinone I, taxifolin, rhoifolin, xanthoangelol E, zingerol etc. isolated from plants could also be potential drug candidates against COVID-19. Moreover, these could also show promising inhibitory effects against influenza-parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have reported 93 antiviral drug candidates which could be a potential area of research in drug discovery.
(© 2020 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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