Assessing the influence of curcumin in sex-specific oxidative stress, survival and behavior in Drosophila melanogaster .

Autor:	Esquivel AR; Department of Biology, Southern Oregon University, Ashland, OR 97520, USA., Douglas JC; Department of Biology, Southern Oregon University, Ashland, OR 97520, USA., Loughran RM; Department of Biology, Southern Oregon University, Ashland, OR 97520, USA., Rezendes TE; Department of Biology, Southern Oregon University, Ashland, OR 97520, USA., Reed KR; Department of Chemistry, Southern Oregon University, Ashland, OR 97520, USA., Cains THL; Department of Biology, Southern Oregon University, Ashland, OR 97520, USA., Emsley SA; Department of Biology, Southern Oregon University, Ashland, OR 97520, USA., Paddock WA; Department of Institutional Research, Arcadia University, Glenside, PA 19038 USA., Videau P; Department of Biology, Southern Oregon University, Ashland, OR 97520, USA., Koyack MJ; Department of Chemistry, Southern Oregon University, Ashland, OR 97520, USA paddockb@sou.edu koyackm@sou.edu., Paddock BE; Department of Biology, Southern Oregon University, Ashland, OR 97520, USA paddockb@sou.edu koyackm@sou.edu.
Jazyk:	angličtina
Zdroj:	The Journal of experimental biology [J Exp Biol] 2020 Nov 20; Vol. 223 (Pt 22). Date of Electronic Publication: 2020 Nov 20.
DOI:	10.1242/jeb.223867
Abstrakt:	Oxidative stress, which occurs from an imbalance of reactive oxygen and nitrogen species (RONS) and both endogenous and exogenous antioxidants, promotes aging and underlies sex-specific differences in longevity and susceptibility to age-related neurodegeneration. Recent evidence suggests that curcumin, a yellow pigment derived from turmeric and shown to exhibit antioxidant properties as a RONS scavenger, influences the regulation of genetic elements in endogenous antioxidant pathways. To investigate the role of curcumin in sex-specific in vivo responses to oxidative stress, Drosophila were reared on media supplemented with 0.25, 2.5 or 25 mmol l -1 curcuminoids (consisting of curcumin, demethoxycurcumin and bisdemethoxycurcumin) and resistance to oxidative stress and neural parameters were assessed. High levels of curcuminoids exhibited two sex-specific effects: protection from hydrogen peroxide as an oxidative stressor and alterations in turning rate in an open field. Taken together, these results suggest that the influence of curcuminoids as antioxidants probably relies on changes in gene expression and that sexual dimorphism exists in the in vivo response to curcuminoids. Competing Interests: Competing interestsThe authors declare no competing or financial interests. (© 2020. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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