Antibody Therapy Goes to Insects: Monoclonal Antibodies Can Block Plasmodium Transmission to Mosquitoes.

Autor: Coelho CH; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: camila.coelho@nih.gov., Jore MM; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands., Canepa GE; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Barillas-Mury C; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Bousema T; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK., Duffy PE; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: patrick.duffy@nih.gov.
Jazyk: angličtina
Zdroj: Trends in parasitology [Trends Parasitol] 2020 Nov; Vol. 36 (11), pp. 880-883. Date of Electronic Publication: 2020 Oct 06.
DOI: 10.1016/j.pt.2020.08.009
Abstrakt: Malaria eradication is a global priority but requires innovative strategies. Humoral immune responses attack different parasite stages, and antibody-based therapy may prevent malaria infection or transmission. Here, we discuss targets of monoclonal antibodies in mosquito sexual stages of Plasmodium.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: