Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
Autor: | Georgescu T; Centre for Neuroendocrinology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Ladyman SR; Centre for Neuroendocrinology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Brown RSE; Centre for Neuroendocrinology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Grattan DR; Centre for Neuroendocrinology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand. |
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Jazyk: | angličtina |
Zdroj: | Journal of neuroendocrinology [J Neuroendocrinol] 2020 Nov; Vol. 32 (11), pp. e12908. Date of Electronic Publication: 2020 Oct 08. |
DOI: | 10.1111/jne.12908 |
Abstrakt: | In addition to its critical role in lactation, the anterior pituitary hormone prolactin also influences a broad range of other physiological processes. In particular, widespread expression of prolactin receptor (Prlr) in the brain has highlighted pleiotropic roles for prolactin in regulating neuronal function, including maternal behaviour, reproduction and energy balance. Research into the central actions of prolactin has predominately focused on effects on gene transcription via the canonical JAK2/STAT5; however, it is evident that prolactin can exert rapid actions to stimulate activity in specific populations of neurones. We aimed to investigate how widespread these rapid actions of prolactin are in regions of the brain with large populations of prolactin-sensitive neurones, and whether physiological state alters these responses. Using transgenic mice where the Cre-dependent calcium indicator, GCaMP6f, was conditionally expressed in cells expressing the long form of the Prlr, we monitored changes in levels of intracellular calcium ([Ca 2+ ] (© 2020 British Society for Neuroendocrinology.) |
Databáze: | MEDLINE |
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