Association of overweight and obesity with cardiovascular risk factors in patients with atherosclerotic diseases.
| Autor: | Maksimovic M; University of Belgrade, Faculty of Medicine, Institute of Hygiene and Medical Ecology, Belgrade., Vlajinac H; University of Belgrade, Faculty of Medicine, Institute of Epidemiology, Belgrade., Radak D; University of Belgrade, Faculty of Medicine, Dedinje Cardiovascular Institute, Department of Vascular Surgery, Belgrade., Marinkovic J; University of Belgrade, Faculty of Medicine, Institute of Medical Statistics and Informatics, Belgrade., Maksimovic J; University of Belgrade, Faculty of Medicine, Institute of Epidemiology, Belgrade., Jorga J; University of Belgrade, Faculty of Medicine, Institute of Hygiene and Medical Ecology, Belgrade. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of medical biochemistry [J Med Biochem] 2020 Jan 23; Vol. 39 (2), pp. 215-223. |
| DOI: | 10.2478/jomb-2019-0027 |
| Abstrakt: | Background: The aim of this study was to compare demographic, clinical and biochemical characteristics, including inflammatory markers, according to the nutritional status of patients with verified atherosclerotic disease. Methods: This cross-sectional study involved 1045 consecutive patients with verified carotid disease or peripheral arterial disease (PAD). Anthropometric parameters and data on cardiovascular risk factors and therapy for hypertension and hyperlipidemia were collected for all participants. Results: Carotid disease was positively and PAD was negatively associated with body mass index (BMI). Negative association between obesity and PAD was significant only in former smokers, not in current smokers or in patients who never smoked. Overweight and general obesity were significantly related to metabolic syndrome (p < 0.001), lower values of high - density lipoprotein cholesterol (p < 0.001), increased triglycerides (p < 0.001), hyperglycemia (p < 0.001), self-reported diabetes (p < 0.001), hypertension (p < 0.001), high serum uric acid (p < 0.001), increased high sensitivity C-reactive protein (p = 0.020) and former smoking (p = 0.005) after adjustment for age, gender and type of disease. Antihypertensive therapy seems to be less effective in patients who are overweight and obese. Conclusions: In conclusion, overweight and general obesity were significantly related to several cardiovascular risk factors. Competing Interests: Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article. (2020 Milos Maksimovic, Hristina Vlajinac, Djordje Radak, Jelena Marinkovic, Jadranka Maksimovic, Jagoda Jorga, published by CEON/CEES.) |
| Databáze: | MEDLINE |
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