Immune-mediated necrotising myopathy in asymptomatic patients with high creatine kinase.

Autor:	Soares IFZ; Neurosciences, Centro Universitário Saúde ABC, Santo Andre, São Paulo, Brazil., Comprido VF; Neurosciences, Centro Universitário Saúde ABC, Santo Andre, São Paulo, Brazil., Hsu BRRHS; Neurosciences, Centro Universitário Saúde ABC, Santo Andre, São Paulo, Brazil., Alves de Siqueira Carvalho A; Neurosciences, Centro Universitário Saúde ABC, Santo Andre, São Paulo, Brazil alzirasiqueiracarvalho@gmail.com.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2020 Oct 08; Vol. 13 (10). Date of Electronic Publication: 2020 Oct 08.
DOI:	10.1136/bcr-2020-235457
Abstrakt:	Subacute symmetrical proximal muscle weakness and persistent elevated creatine kinase levels are typical of immune-mediated necrotising myopathy (IMNM). These conditions are accompanied by copious myofibre necrosis, degeneration and regeneration with minimal to no inflammation on muscle biopsy. We report two cases (case 1 and case 2) of asymptomatic IMNM from different families with hyperCKaemia associated with positive anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies, respectively, and we also reviewed the literature. There are only a few previous descriptions of patients with asymptomatic IMNM.The disease onset could be insidious and lead to delayed diagnosis and treatment. We recommend testing for the anti-HMGCR and anti-SRP antibodies in patients with idiopathic hyperCKaemia because they could show no symptoms of this disorder. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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