First trimester cerebral appearance in the presence of closed spina bifida with myelomeningocele, part of the oeis complex.

Autor:	Ungureanu DR; Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova Faculty of Medicine, Craiova, Romania., Zorila LG; Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova Faculty of Medicine, Craiova, Romania zorilalucian@gmail.com.; Obstetrics and Gynecology, Medgin Prenatal Diagnostic Unit, Craiova, Dolj, Romania., Capitanescu RG; Obstetrics and Gynecology, Medgin Prenatal Diagnostic Unit, Craiova, Dolj, Romania.; Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Craiova, Romania., Iliescu DG; Obstetrics and Gynecology, Medgin Prenatal Diagnostic Unit, Craiova, Dolj, Romania.; Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2020 Oct 08; Vol. 13 (10). Date of Electronic Publication: 2020 Oct 08.
DOI:	10.1136/bcr-2020-235395
Abstrakt:	Our communication presents a prenatally detected case with severe spinal defect detected in the first trimester of pregnancy, accompanied by a large skin-covered myelomeningocele but normal cranio-cerebral structural appearance.These findings suggest that in the first trimester, the extent of the spinal defect, the cerebrospinal fluid leakage to a large, but skin-covered, meningocele and fixation of the spinal cord at the lesion are not sufficient to determine downward hindbrain displacement and the development of secondary signs for open spina bifida.Therefore, we suggest a careful evaluation of the fetal cerebral features if a meningocele is detected. The presence of the skin covering the lesion may not be evident in the first trimester, but the absence of intracranial open spina bifida markers may indicate a 'closed' spinal defect, which generally associates a good neurological outcome. Also, studies aimed to investigate the accuracy of the intracranial features for open spina bifida detection should consider the possibility of 'closed' myelomeningoceles to avoid incorrect correlations. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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