Clinical evaluation of the synbiotic Prodefen Plus® in the prevention of the antibiotic-associated diarrhoea in subjects requiring antibiotic treatment.
| Autor: | Guridi CB; Clínica Dental Dra. Coro Guridi Rodríguez, Av. Francisco de Goya 16, 50006 Zaragoza, Spain., Serena AR; Clínica Dental Dra Marina Tarrío, Paseo de Calanda 1, 50010 Zaragoza, Spain., Cabrera SG; Clínica Dental Gallego, Avinguda de Pérez Galdós 2, 46007 València, Spain., Fernández IA; Maxiloimplant Clínica Dental, Calle de Guareña, 5, 28044 Madrid, Spain., Hernández CR; Clínica Dental Royo, Av. Oscar Espla 21, 03007 Alacant, Spain., Vivanco BM; Clínica Dental Beatriz Martín Vivanco, C/ Ana Albi 19 bajo, 28025 Madrid, Spain., Melguizo MC; Clínica Dental Sonrisas, C. de la Princesa 90, piso 2°, 2ª, 28008 Madrid, Spain., Suárez-Almarza J; ITF Research Pharma S.L.U., Grupo Italfarmaco, Calle s San Rafael 3, 28108 Alcobendas, Spain., Nieto-Magro C; ITF Research Pharma S.L.U., Grupo Italfarmaco, Calle s San Rafael 3, 28108 Alcobendas, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Beneficial microbes [Benef Microbes] 2020 Oct 12; Vol. 11 (6), pp. 535-545. Date of Electronic Publication: 2020 Oct 09. |
| DOI: | 10.3920/BM2020.0062 |
| Abstrakt: | Prodefen® is a dietary food supplement formulated as a synbiotic that has shown additional benefit to the standard supportive therapy in the management of acute viral diarrhoea in children. There is scarce evidence of this synbiotic in adults. The objective of this randomised double blind placebo-controlled clinical trial was to evaluate the efficacy and safety of Prodefen Plus® in the prevention of antibiotic-associated diarrhoea (AAD) in an adult population requiring either antibiotic treatment for an oral infection or antibiotic prophylaxis for a dental surgical procedure in a dental consultation. 151 subjects were randomised to the active (synbiotic) or control arm (placebo) for 14 days. There was a significantly higher reduction in the AAD incidence, and an improvement in the stool consistency in the active group. A higher reduction in both the frequency and duration of the diarrhoea episodes in the active group was also observed, as it was an improved perception of the diarrhoea severity. Overall, the study medication was well tolerated. In conclusion, results from this study confirm the beneficial effect of the synbiotic administered as adjuvant therapy in preventing the antibiotic-associated diarrhoea. |
| Databáze: | MEDLINE |
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