| Autor: |
Musavi H; Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran., Abazari O; Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Barartabar Z; Department of Clinical Biochemistry, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran., Kalaki-Jouybari F; Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran., Hemmati-Dinarvand M; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Esmaeili P; Department of Immunology and Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran., Mahjoub S; Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.; Department of Pathology, University of Kiel, Kiel, Germany. |
| Abstrakt: |
In December 2019, a new infectious complication called CoronaVirus Infectious Disease-19, briefly COVID-19, caused by SARS-COV-2, is identified in Wuhan, China. It spread all over the world and became a pandemic. In many individuals who had suffered SARS-COV-2 infection, cytokine storm starts through cytokine overproduction and leads to Acute Respiratory Syndrome (ARS), organ failure, and death. According to the obtained evidence, Vitamin D (VitD) enhances the ACE2/Ang(1-7)/MasR pathway activity, and it also reduces cytokine storms and the ARS risk. Therefore, VitD intake may be beneficial for patients with SARS-COV-2 infection exposed to cytokine storm but do not suffer hypotension. In the present review, we have explained the effects of VitD on the renin-angiotensin system (RAS) function and angiotensin-converting enzyme2 (ACE2) expression. Furthermore, we have reviewed the biochemical and immunological effects of VitD on immune function in the underlying diseases and its role in the COVID-19 pandemic. |
