| Autor: |
Zhu LJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Wang MQ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Qin Y; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Wang MN; The National Orchid Conservation Center of China, The Orchid Conservation & Research Center of Shenzhen, Shenzhen 518114, China., Zhang GQ; The National Orchid Conservation Center of China, The Orchid Conservation & Research Center of Shenzhen, Shenzhen 518114, China., Niu LT; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Chen JB; The National Orchid Conservation Center of China, The Orchid Conservation & Research Center of Shenzhen, Shenzhen 518114, China., Zhang X; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Yao XS; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.; Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, China. |
| Abstrakt: |
Two new dibenzyl derivatives, dendrocandins V-W ( 1 - 2 ), together with six known compounds ( 3 - 8 ), have been isolated from the dried stems of Dendrobium catenatum . Their structures were mainly elucidated on the basis of HRESIMS, one- and two-dimensional NMR techniques. The isolated compounds 5 - 8 were evaluated in vitro for their antioxidant and hypoglycemic activities. Compound 8 showed moderate potent DPPH scavenging activity with IC 50 value of 34.45 ± 1.07 µM. And compounds 5 , 7 - 8 exhibited significant ABTS radical scavenging activities with IC 50 values of 10.03 ± 0.88, 5.32 ± 1.13 and 9.01 ± 1.39 µM. Compounds 6 - 7 showed potent α-glucosidase inhibitory activities with IC 50 values of 36.05 ± 0.67 and 159.59 ± 0.86 µM. |
