Adverse effects of perinatal illness severity on neurodevelopment are partially mediated by early brain abnormalities in infants born very preterm.

Autor: Logan JW; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA. JWells.Logan@NationwideChildrens.org., Tan J; Biostatistics Resource at Nationwide Children's Hospital, Nationwide Children's Hospital, Columbus, OH, USA., Skalak M; Cincinnati Children's Hospital Medical Center, Perinatal Institute, Cincinnati, OH, USA., Fathi O; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA., He L; Cincinnati Children's Hospital Medical Center, Perinatal Institute, Cincinnati, OH, USA., Kline J; Cincinnati Children's Hospital Medical Center, Perinatal Institute, Cincinnati, OH, USA., Klebanoff M; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.; Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA., Parikh NA; Cincinnati Children's Hospital Medical Center, Perinatal Institute, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2021 Mar; Vol. 41 (3), pp. 519-527. Date of Electronic Publication: 2020 Oct 07.
DOI: 10.1038/s41372-020-00854-1
Abstrakt: Background: We sought to determine the mediating effects of magnetic resonance imaging (MRI) biomarkers at term gestation on the relationship between perinatal illness severity and neurodevelopment.
Methods: The Clinical Risk Index for Babies-second edition (CRIB-II) was correlated with indices of brain maturation or injury and neurodevelopment at 2-year follow-up in infants born less than 32 weeks gestation. Using a counterfactual mediation analysis, associations between CRIB-II, MRI biomarkers, and neurodevelopment were confirmed, followed by an assessment of the mediating effects of MRI biomarkers on the relationship between CRIB-II and neurodevelopment.
Results: CRIB-II correlated significantly with neurodevelopment and MRI biomarkers of brain injury or cortical maturation. Two MRI biomarkers, cortical surface area and global injury score, were associated with neurodevelopmental scores at follow-up and included in mediation analyses.
Conclusion: Biomarkers of cortical maturation or brain injury at term-equivalent age mediated a substantial portion of the risks conveyed by perinatal illness severity on neurodevelopmental outcomes at 2 years corrected age.
Databáze: MEDLINE
Externí odkaz: