Transient loss of endothelial cells in human spiral artery remodelling during early pregnancy: Challenging the dogma.

Autor: Bulmer JN; Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Innes BA; Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Robson SC; Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Lash GE; Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. Electronic address: gendie.lash@hotmail.com.
Jazyk: angličtina
Zdroj: Placenta [Placenta] 2020 Nov; Vol. 101, pp. 230-233. Date of Electronic Publication: 2020 Oct 01.
DOI: 10.1016/j.placenta.2020.10.003
Abstrakt: Spiral artery (SpA) remodelling is essential for a successful pregnancy and is best described by its morphological features; vascular smooth muscle cell separation and loss, vessel dilatation, and invasion by extravillous trophoblast cells (EVT). Current opinion holds that EVT fully replace the endothelial cells (EC) of the SpA and take on EC-like characteristics. Placental bed biopsies (6-20 weeks gestation) were immunostained for EC and EVT, showing transient loss of EC. In vessels containing an endovascular EVT plug (n = 28) 77.6 ± 19.3% of the lumen was covered by EC while in vessels without endovascular EVT (n = 100) it was 100 ± 0%.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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