ORAL RUTIN SUSPENSION INTERVENE IN HEPATIC HYPERPLASIA IN RATS.
| Autor: | Barros PP; Pontifícia Universidade Católica de Campinas, Faculdade de Ciências Farmacêuticas, Campinas, SP, Brasil., Eisinger ABC; Pontifícia Universidade Católica de Campinas, Faculdade de Ciências Farmacêuticas, Campinas, SP, Brasil., GonÇalves GMS; Pontifícia Universidade Católica de Campinas, Programa de Pós Graduação em Ciências da Saúde, Campinas, SP, Brasil., Silva GHD; Pontifícia Universidade Católica de Campinas, Faculdade de Ciências Farmacêuticas, Campinas, SP, Brasil. |
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| Jazyk: | angličtina |
| Zdroj: | Arquivos de gastroenterologia [Arq Gastroenterol] 2020 Jul-Sep; Vol. 57 (3), pp. 296-299. |
| DOI: | 10.1590/S0004-2803.202000000-54 |
| Abstrakt: | Background: Rutin is a flavonol glycoside that can be found in a wide variety of vegetables and has activity, anti-cancer, anti-inflammatory and anti-diabetic properties. Objective: This study investigated the effect of rutin oral administration on Wistar rats submitted to hepatic hyperplasia after partial hepatectomy (PH). Methods: To achieve this, we considered the analysis of hepatic hyperplastic and plasma biochemical activity of Wistar rats, subjected to treatment with rutin 40 mg/kg/day for 10 days in group 1 (G1) or saline in group 2 (G2), followed by partial hepatectomy. Results: The results indicated an increase in the number of mitoses after 24 hours and 48 hours (P=0.0022 and P=0.0152, respectively) of PH in the group that received rutin, as well as an increase in AST serum levels after 24 hours (P=0.0159) and 48 hours (P=0.0158) and alkaline phosphatase after 24 hours (P=0.015) in the same group, in relation to the respective controls. The group that received rutin showed a more evident variation than the control group when comparing the 24 hour and 48 hour results regarding AST, number of mitoses and number of apoptosis (P<0.005). Conclusion: It was concluded that rutin intervened in hepatic hyperplasia after 24 hours and 48 hours of PH, favoring hepatic hyperplasia. |
| Databáze: | MEDLINE |
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