Different forms of traumatic brain injuries cause different tactile hypersensitivity profiles.

Autor:	Wattiez AS; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, United States.; Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, United States., Castonguay WC; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, United States.; Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, United States., Gaul OJ; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, United States., Waite JS; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, United States., Schmidt CM; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, United States., Reis AS; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, United States., Rea BJ; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, United States.; Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, United States., Sowers LP; Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, United States., Cintrón-Pérez CJ; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH, United States.; Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, United States.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, United States., Vázquez-Rosa E; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH, United States.; Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, United States.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, United States., Pieper AA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH, United States.; Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, United States.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.; Weill Cornell Autism Research Program, Weill Cornell Medicine of Cornell University, New York, NY, United States.; Department of Neuroscience, Case Western Reserve University, School of Medicine, Cleveland, OH, United States., Russo AF; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, United States.; Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, United States.; Department of Neurology, University of Iowa, Iowa City, IA, United States.
Jazyk:	angličtina
Zdroj:	Pain [Pain] 2021 Apr 01; Vol. 162 (4), pp. 1163-1175.
DOI:	10.1097/j.pain.0000000000002103
Abstrakt:	Abstract: Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been understudied, in large part because of the lack of well-characterized laboratory animal models. We have addressed this gap in the field by characterizing the tactile sensory profile of 2 nonpenetrating models of PTH. We show that multimodal traumatic brain injury, administered by a jet-flow overpressure chamber that delivers a severe compressive impulse accompanied by a variable shock front and acceleration-deceleration insult, produces long-term tactile hypersensitivity and widespread sensitization. These are phenotypes reminiscent of PTH in patients, in both cephalic and extracephalic regions. By contrast, closed head injury induces only transient cephalic tactile hypersensitivity, with no extracephalic consequences. Both models show a more severe phenotype with repetitive daily injury for 3 days, compared with either 1 or 3 successive injuries in a single day, providing new insight into patterns of injury that may place patients at a greater risk of developing PTH. After recovery from transient cephalic tactile hypersensitivity, mice subjected to closed head injury demonstrate persistent hypersensitivity to established migraine triggers, including calcitonin gene-related peptide and sodium nitroprusside, a nitric oxide donor. Our results offer the field new tools for studying PTH and preclinical support for a pathophysiologic role of calcitonin gene-related peptide in this condition. (Copyright © 2020 International Association for the Study of Pain.)
Databáze:	MEDLINE
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