Gold Drugs with {Au(PPh 3 )} + Moiety: Advantages and Medicinal Applications.

Autor: Stenger-Smith JR; Department of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA., Mascharak PK; Department of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2020 Nov 18; Vol. 15 (22), pp. 2136-2145. Date of Electronic Publication: 2020 Oct 29.
DOI: 10.1002/cmdc.202000608
Abstrakt: Following the success of Auranofin as an anti-arthritic drug, search for novel gold drugs has afforded a large number of [L-Au(PPh 3 )] complexes that exhibit notable salutary effects. Unlike Au(III)-containing species, these gold complexes with {Au(PPh 3 )} + moiety are stable in biological media and readily exchange L with S- and Se-containing enzymes or proteins. Such exchange leads to rapid reduction of microbial loads or induction of apoptotic cell death at malignant sites. In many cases the lipophilic {Au(PPh 3 )} + moiety delivers a desirable toxic L to the specific cellular target in addition to exhibiting its own beneficial activity. Further research and utilization of this synthon in drug design could lead to novel chemotherapeutics for treatment of drug-resistant pathogens and cancers.
(© 2020 Wiley-VCH GmbH.)
Databáze: MEDLINE
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