Cytomegalovirus pneumonitis-induced secondary hemophagocytic lymphohistiocytosis and SIADH in an immunocompetent elderly male literature review.

Autor:	Patil SM; University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.; Department of Medicine, Division of Infectious Diseases, USA., Beck PP; University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.; Department of Medicine, Division of Infectious Diseases, USA., Patel TP; University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.; Department of Medicine, Division of Pulmonary, Critical Care and Environmental Medicine, USA., Hunter MP; University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.; Department of Medicine, Division of Pulmonary, Critical Care and Environmental Medicine, USA., Johnson J; University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.; Department of Medicine, Division of Pulmonary, Critical Care and Environmental Medicine, USA., Acevedo BA; University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.; Department of Medicine, Division of Infectious Diseases, USA., Roland W; University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.; Department of Medicine, Division of Infectious Diseases, USA.
Jazyk:	angličtina
Zdroj:	IDCases [IDCases] 2020; Vol. 22, pp. e00972. Date of Electronic Publication: 2020 Oct 02.
DOI:	10.1016/j.idcr.2020.e00972
Abstrakt:	Hemophagocytic lymphohistiocytosis (HLH) is also known as hemophagocytic syndrome. It is a lethal hematologic condition due to a dysregulated immune response which results in inappropriately activated macrophages damaging host tissues. Based on the etiology, HLH can be primary (genetic) or secondary (acquired). The most common cause of a secondary HLH is an infection. Viral infections are the most common cause of secondary HLH. Among the viral causes of secondary HLH, Epstein-Barr virus is the most common etiologic agent. Cytomegalovirus (CMV) is a common causative pathogen in the immunocompromised host but is rare in an immunocompetent adult. In infection- associated secondary HLH, treatment includes antimicrobial therapy. HLH carries a high mortality and morbidity rate as it is an underdiagnosed clinical condition. Successful early diagnosis allows for adequate time for curative therapy. Treatment for HLH includes chemotherapy, immunomodulators, and a hematopoietic stem-cell transplant. The 2004 diagnostic criteria set by the Histiocyte Society serves as a guide to make an earlier clinical diagnosis. A review of PubMed literature revealed only five reported cases of CMV-induced HLH. We describe the sixth case of CMV pneumonitis-induced HLH and syndrome of inappropriate antidiuretic hormone secretion in a 72-year-old White male. He was treated successfully with oral valganciclovir and corticosteroids. (© 2020 The Authors.)
Databáze:	MEDLINE
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