Temporal variation of total mercury levels in the hair of pregnant women from the Maternal-Infant Research on Environmental Chemicals (MIREC) study.

Autor: Lukina AO; Environmental Health Science & Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. Electronic address: anna.lukina@canada.ca., Fisher M; Environmental Health Science & Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada., Khoury C; Environmental Health Science & Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. Electronic address: cheryl.khoury@canada.ca., Than J; Environmental Health Science & Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada., Guay M; Environmental Health Science & Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada., Paradis JF; Health Products and Food Laboratories, Regulatory Operations and Regions Branch, Health Canada, Longueuil, QC, Canada., Arbuckle TE; Environmental Health Science & Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada., Legrand M; Family Physician, GMF Wakefield, 777 Riverside Dr., Wakefield, QC, Canada.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2021 Feb; Vol. 264 (Pt 1), pp. 128402. Date of Electronic Publication: 2020 Sep 24.
DOI: 10.1016/j.chemosphere.2020.128402
Abstrakt: Prenatal exposure to total mercury (T-Hg) comes from both natural and anthropogenic sources. T-Hg can cross the blood-brain and placental barriers, and may be associated with future neurological and physiological dysfunctions. Scalp hair is an optimal and non-invasive indicator of chronic T-Hg exposure. As part of the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, hair samples from 350 women were collected within weeks after giving birth, to determine temporal variations in T-Hg levels from preconception to delivery, and to compare these levels to corresponding levels measured in other matrices (maternal and umbilical cord blood, and infant's meconium). A maximum of 12 one-cm hair segments were cut starting at the scalp; segments closer to the scalp reflected recent exposure (within the last month). For proper comparison, the hair segments were matched with the collection dates for other matrices. GM hair T-Hg levels greatly decreased during pregnancy, from 0.26 μg g -1 (preconception or full-length hair) to 0.18 μg g -1 (at delivery or segments closer to the scalp). A similar decreasing trend was found for T-Hg in maternal blood: 1st trimester (0.60 μg L -1 ) to 3rd trimester (0.47 μg L -1 ). The median hair-to-blood ratios of T-Hg levels varied from 364 (1st trimester), to 408 (3rd trimester), to 229 (cord blood). Very low T-Hg levels were detected in meconium. Mercury levels in blood and hair correlated with consumption of large predatory fish.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: