Rats recognize spatial and temporal attributes in a new object recognition memory task with multiple trials.

Autor: Araujo APC; Memory and Cognition Studies Laboratory, Department of Psychology, Federal University of Paraíba, João Pessoa, PB, Brazil., de Lucena JD; Memory and Cognition Studies Laboratory, Department of Psychology, Federal University of Paraíba, João Pessoa, PB, Brazil; Faculdade de Santa Maria, Cajazeiras, PB, Brazil., Drieskens DC; Memory and Cognition Studies Laboratory, Department of Psychology, Federal University of Paraíba, João Pessoa, PB, Brazil; Brain Institute, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Neves LR; Memory and Cognition Studies Laboratory, Department of Psychology, Federal University of Paraíba, João Pessoa, PB, Brazil; Brain Institute, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Pugliane KC; Memory and Cognition Studies Laboratory, Department of Psychology, Federal University of Paraíba, João Pessoa, PB, Brazil., Belchior HA; Faculdade de Ciências da Saúde do Trairí, Universidade federal do Rio Grande do norte, Santa Cruz, RN, Brazil., Castelo-Branco R; Memory and Cognition Studies Laboratory, Department of Psychology, Federal University of Paraíba, João Pessoa, PB, Brazil., Barbosa FF; Memory and Cognition Studies Laboratory, Department of Psychology, Federal University of Paraíba, João Pessoa, PB, Brazil. Electronic address: barbosa.flaviof@gmail.com.
Jazyk: angličtina
Zdroj: Journal of neuroscience methods [J Neurosci Methods] 2021 Jan 15; Vol. 348, pp. 108936. Date of Electronic Publication: 2020 Oct 03.
DOI: 10.1016/j.jneumeth.2020.108936
Abstrakt: Background: Episodic-like memory tasks based on the spontaneous exploration of objects are commonly applied in one-trial protocols. However, multiple-trial designs are known to reduce animal numbers and data variance, providing faster accumulation of data.
New Method: In this study, we devised a new object recognition memory task for rats that carry out multiple trials per session. We developed three types of continual trial tasks: a longer protocol, a shorter protocol, and a protocol in which the experimental session was divided into two days.
Results: In our design, rats expressed temporal and spatial memory, but not what-where-when content integration. We found that shorter protocols were more efficient to evaluate memory capabilities.
Comparison With Existing Methods: To the best of our knowledge, it is the first object recognition task with multiple trials that simultaneously assess the temporal and spatial aspects of episodic-like memory.
Conclusions: We suggest that our task is suitable for the simultaneous measurements of brain functions related to spatial and temporal attributes in rats.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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