Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl-Kappa-Carrageenan Produced by a Green Process.

Autor: Madruga LYC; Institute of Chemistry, Federal University of Rio Grande do Norte (UFRN), Natal, RN, 59078-970, Brazil.; Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, 80523, USA., Balaban RC; Institute of Chemistry, Federal University of Rio Grande do Norte (UFRN), Natal, RN, 59078-970, Brazil., Popat KC; School of Advanced Materials Discovery, Colorado State University, Fort Collins, CO, 80523, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, 80523, USA.; Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, 80523, USA., Kipper MJ; Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, 80523, USA.; School of Advanced Materials Discovery, Colorado State University, Fort Collins, CO, 80523, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, 80523, USA.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2021 Jan; Vol. 21 (1), pp. e2000292. Date of Electronic Publication: 2020 Oct 05.
DOI: 10.1002/mabi.202000292
Abstrakt: This study presents a new type of biocompatible nanofiber based on poly(vinyl alcohol) (PVA) and carboxymethyl-kappa-carrageenan (CMKC) blends, produced with no generation of hazardous waste. The nanofibers are produced by electrospinning using PVA:CMKC blends with ratios of 1:0, 1:0.25, 1:0.4, 1:0.5, and 1:0.75 (w/w PVA:CMKC) in aqueous solution, followed by thermal crosslinking. The diameter of the fibers is in the nanometer scale and below 300 nm. Fourier transform infrared spectroscopy shows the presence of the carboxyl and sulfate groups in all the fibers with CMKC. The nanofibers from water-soluble polymers are stabilized by thermal crosslinking. The incorporation of CMKC improves cytocompatibility, biodegradability, cell growth, and cell adhesion, compared to PVA nanofibers. Furthermore, the incorporation of CMKC modulates phenotype of human adipose-derived stem cells (ADSCs). PVA/CMKC nanofibers enhance ADSC response to osteogenic differentiation signals and are therefore good candidates for application in tissue engineering to support stem cells.
(© 2020 Wiley-VCH GmbH.)
Databáze: MEDLINE
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