Low titer group O whole blood resuscitation: Military experience from the point of injury.

Autor:	Fisher AD; From the Medical Command (A.D.F.), Texas Army National Guard, Austin, Texas; Department of Surgery (A.D.F.), UNM School of Medicine, Albuquerque, New Mexico; Prehospital Research and Innovation in Military Expeditionary Environments (A.D.F.); Maneuver Center of Excellence (E.A.M.), Fort Benning, Georgia; Joint Special Operations Command (M.A.B.), Fort Bragg, North Carolina; Army Blood Program (J.B.C.), US Army Medical Command, JBSA Fort Sam Houston, Texas; 75th Ranger Regiment (R.K.), Fort Benning, Georgia; Department of Military and Emergency Medicine (R.K.), USUHS, Bethesda, Maryland; Joint Trauma System (M.A.R., J.M.G., S.A.S.), Defense Health Agency; and United States Army Institute of Surgical Research (A.P.C.), JBSA Fort Sam Houston, Texas., Miles EA, Broussard MA, Corley JB, Knight R, Remley MA, Cap AP, Gurney JM, Shackelford SA
Jazyk:	angličtina
Zdroj:	The journal of trauma and acute care surgery [J Trauma Acute Care Surg] 2020 Oct; Vol. 89 (4), pp. 834-841.
DOI:	10.1097/TA.0000000000002863
Abstrakt:	Introduction: In the far forward combat environment, the use of whole blood is recommended for the treatment of hemorrhagic shock after injury. In 2016, US military special operations teams began receiving low titer group O whole blood (LTOWB) for use at the point of injury (POI). This is a case series of the initial 15 patients who received LTOWB on the battlefield. Methods: Patients were identified in the Department of Defense Trauma Registry, and charts were abstracted for age, sex, nationality, mechanism of injury, injuries and physiologic criteria that triggered the transfusion, treatments at the POI, blood products received at the POI and the damage-control procedures done by the first surgical team, next level of care, initial interventions by the second surgical team, Injury Severity Score, and 30-day survival. Descriptive statistics were used to characterize the clinical data when appropriate. Results: Of the 15 casualties, the mean age was 28, 50% were US military, and 63% were gunshot wounds. Thirteen patients survived to discharge, one died of wounds after arrival at the initial resuscitative surgical care, and two died prehospital. The mean Injury Severity Score was 21.31 (SD, 18.93). Eleven (68%) of the causalities received additional blood products during evacuation/role 2 and/or role 3. Vital signs were available for 10 patients from the prehospital setting and 9 patients upon arrival at the first surgical capable facility. The mean systolic blood pressure was 80.5 prehospital and 117 mm Hg (p = 0.0002) at the first surgical facility. The mean heart rate was 105 beats per minute prehospital and 87.4 beats per minute (p = 0.075) at the first surgical facility. The mean hospital stay was 24 days. Conclusion: The use of cold-stored LTOWB at POI is feasible during combat operations. Further data are needed to validate and inform best practice for POI transfusion. Level of Evidence: Therapeutic study, level V.
Databáze:	MEDLINE
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