Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses.

Autor:	Papadimitriou KI; Department of Computer Science, University College London, London, WC1E 6BT, UK.; These authors contributed equally to this work., Vidal Rosas EE; Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.; These authors contributed equally to this work., Zhang E; Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK., Cooper RJ; Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK., Hebden JC; Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK., Arridge SR; Department of Computer Science, University College London, London, WC1E 6BT, UK., Powell S; Faculty of Engineering, University of Nottingham, Nottingham, NG7 2RD, UK.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2020 Jun 02; Vol. 11 (7), pp. 3477-3490. Date of Electronic Publication: 2020 Jun 02 (Print Publication: 2020).
DOI:	10.1364/BOE.393586
Abstrakt:	Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, with their associated cost, complexity, and size. In this work, we present an alternative approach that employs spread-spectrum excitation to enable the development of a small, low-cost, dual-wavelength system using vertical-cavity surface-emitting lasers. Since the optimal wavelengths and drive parameters for optical spectroscopy are not served by commercially available modules as used in our previous single-wavelength demonstration platform, we detail the design of a custom instrument and demonstrate its performance in resolving haemodynamic changes in human subjects during apnoea and cognitive task experiments. Competing Interests: The authors declare that there are no conflicts of interest related to this article. (Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.)
Databáze:	MEDLINE
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