Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1-7.

Autor:	Silva GM; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vitória de Santo Antão, Brazil., França-Falcão MS; Center of Biotechnology, Federal University of Paraiba, João Pessoa, Brazil., Calzerra NTM; Paraiba Higher Education Institute, IESP, Cabedelo, Brazil., Luz MS; Center of Biotechnology, Federal University of Paraiba, João Pessoa, Brazil., Gadelha DDA; Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., Balarini CM; Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., Queiroz TM; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vitória de Santo Antão, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2020 Sep 03; Vol. 11, pp. 1067. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
DOI:	10.3389/fphys.2020.01067
Abstrakt:	Atherosclerosis is the leading cause of vascular disease worldwide and contributes significantly to deaths from cardiovascular complications. There is a remarkably close relationship between atherosclerotic plaque formation and the activation of renin-angiotensin system (RAS). However, depending on which RAS pathway is activated, pro- or anti-atherogenic outcomes may be observed. This brief review focuses on the role of three of the most important pieces of RAS axis, angiotensin II (Ang-II), angiotensin converting enzyme type 2 (ACE2), and angiotensin 1-7 (Ang-1-7) and their involvement in atherosclerosis. We focused on the effects of these molecules on vascular function and inflammation, which are important determinants of atherogenesis. Furthermore, we highlighted potential pharmacological approaches to treat this disorder. (Copyright © 2020 Silva, França-Falcão, Calzerra, Luz, Gadelha, Balarini and Queiroz.)
Databáze:	MEDLINE
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