Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C-positive organ transplantation.

Autor: Story MT; Department Medicine, Division of Nephrology, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA., Sanders ML; Department Medicine, Division of Nephrology, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA.; Iowa City VA Health Care System, Iowa City, IA, USA., Bashir AA; Department of Pathology, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA., Longo JM; Iowa City VA Health Care System, Iowa City, IA, USA.; Department of Radiology, University of Iowa Roy and Lucille Iowa Carver College of Medicine, Iowa City, IA, USA., Abel SL; Iowa City VA Health Care System, Iowa City, IA, USA., Dollard SC; Centers for Disease Control and Prevention, Atlanta, GA, USA., Grodstein EI; Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA., Thomas CP; Department Medicine, Division of Nephrology, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA.; Iowa City VA Health Care System, Iowa City, IA, USA., Katz DA; Iowa City VA Health Care System, Iowa City, IA, USA.; Department of Surgery, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA.
Jazyk: angličtina
Zdroj: Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2021 Apr; Vol. 23 (2), pp. e13481. Date of Electronic Publication: 2020 Oct 22.
DOI: 10.1111/tid.13481
Abstrakt: Kaposi sarcoma (KS) following kidney transplantation can result from recipient reactivation of latent human herpesvirus 8 (HHV-8) infection or activation of donor-acquired HHV-8 infection. Post-transplant KS typically manifests with cutaneous pathology, but rare cases of renal allograft involvement have been reported. We describe two cases of donor-derived HHV-8 infection in two hepatitis C (HCV) viremia-negative transplant recipients who each received a kidney from a donor with HCV viremia. One recipient did not develop KS while the other presented with acute kidney injury caused by extensive KS infiltration of the renal parenchyma and metastatic disease. This report reviews the literature for cases of KS involving the renal allograft and highlights an unexpected consequence of deliberate HCV-positive organ transplantation.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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