IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators.

Autor:	Wehrli M; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland., Schneider C; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland., Cortinas-Elizondo F; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland., Verschoor D; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland., Frias Boligan K; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland., Adams OJ; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland., Hlushchuk R; Institute of Anatomy, University of Bern, 3012 Bern, Switzerland., Engelmann C; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Daudel F; Intensive Care Unit, Spital Thun, 3600 Thun, Switzerland., Villiger PM; Department of Rheumatology/Clinical Immunology/Allergology, University Hospital Bern, 3008 Bern, Switzerland., Seibold F; Gastroenterologie, Spitalnetz Bern, 3004 Bern, Switzerland.; Gastroenterologie, Praxis Balsiger, Seibold und Partner am Lindenhofspital, 3012 Bern, Switzerland., Yawalkar N; Department of Dermatology, University Hospital Bern, University of Bern, 3010 Bern, Switzerland., Vonarburg C; Research, CSL Behring, 3014 Bern, Switzerland., Miescher S; Research, CSL Behring, 3014 Bern, Switzerland., Lötscher M; Research, CSL Behring, 3014 Bern, Switzerland., Kaufmann T; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland., Münz C; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Mueller C; Institute of Pathology, University of Bern, 3008 Bern, Switzerland; and., Djonov V; Institute of Anatomy, University of Bern, 3012 Bern, Switzerland., Simon HU; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland.; Department of Clinical Immunology and Allergology, Sechenov University, Moscow 119991, Russia., von Gunten S; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland; stephan.vongunten@pki.unibe.ch.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Nov 15; Vol. 205 (10), pp. 2640-2648. Date of Electronic Publication: 2020 Oct 02.
DOI:	10.4049/jimmunol.1900883
Abstrakt:	IVIG preparations consisting of pooled IgG are increasingly used for the treatment of autoimmune diseases. IVIG is known to regulate the viability of immune cells, including neutrophils. We report that plasma-derived IgA efficiently triggers death of neutrophils primed by cytokines or TLR agonists. IgA-mediated programmed neutrophil death was PI3K-, p38 MAPK-, and JNK-dependent and evoked anti-inflammatory cytokines in macrophage cocultures. Neutrophils from patients with acute Crohn's disease, rheumatoid arthritis, or sepsis were susceptible to both IgA- and IVIG-mediated death. In contrast to IVIG, IgA did not promote cell death of quiescent neutrophils. Our findings suggest that plasma-derived IgA might provide a therapeutic option for the treatment of neutrophil-associated inflammatory disorders. (Copyright © 2020 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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