No effect of a low dose of metformin on the lipid profile, body mass index and weight gain in pregnant women with obesity: A randomized trial.

Autor: Dienstmann G; University of the Region of Joinville - UNIVILLE, Joinville, SC, Brazil. Electronic address: guidbio@gmail.com., Nascimento IBD; University of the Region of Joinville - UNIVILLE, Joinville, SC, Brazil. Electronic address: iramar.nascimento@udesc.br., Sales WB; University of the Region of Joinville - UNIVILLE, Joinville, SC, Brazil. Electronic address: willianbarbosasales@gmail.com., Leite Ramos de Souza M; University of the Region of Joinville - UNIVILLE, Joinville, SC, Brazil. Electronic address: matheus.leite.souza@gmail.com., Silva GDD; University of the Region of Joinville - UNIVILLE, Joinville, SC, Brazil. Electronic address: gra_dutra@hotmail.com., de Oliveira LC; University of the Region of Joinville - UNIVILLE, Joinville, SC, Brazil. Electronic address: laricdo@gmail.com., Silva JC; University of the Region of Joinville - UNIVILLE, Joinville, SC, Brazil. Electronic address: jeancarlsilva@gmail.com.
Jazyk: angličtina
Zdroj: Obesity research & clinical practice [Obes Res Clin Pract] 2020 Nov - Dec; Vol. 14 (6), pp. 561-565. Date of Electronic Publication: 2020 Sep 30.
DOI: 10.1016/j.orcp.2020.09.005
Abstrakt: Objective: Evaluate the lipid profile, Body Mass Index (BMI) and weight gain of pregnant women with obesity and the effect of a low dose (1000 mg/day) of metformin hydrochloride on these parameters.
Methods: A randomized clinical trial was performed from October 31th, 2014 to January 25th, 2018 with pregnant women diagnosed with obesity by arrival BMI ≥ 30.0 kg/m 2 . The participants were randomized into two groups: metformin and control. All pregnant women received standard prenatal follow-up and the same instructions of diet and physical exercise. Laboratory tests were performed at three different times: first moment with gestational age (GA) < 20 weeks, second (GA 24-28 weeks) and third (GA 32-34 weeks) measuring maternal serum levels of total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides (TG) as well as weight gain and BMI were monitored.
Results: A total of 424 pregnant women with obesity were evaluated. Of these, 218 (51.41%) composed the control group and 206 (48.59%) the metformin group. There was no difference of lipid profile, BMI and weight gain values between groups during the 1st, 2nd and 3rd evaluation moments. A significant difference was observed, only in the BMI, HDL and TG values from 1st to 3rd evaluation moments.
Conclusion: Low dose (1000 mg/day) of the drug showed no effect on the lipid profile, BMI and weight gain in pregnant women with obesity in metformin group during the evaluation moments.
(Copyright © 2020 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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