| Autor: |
Reid G; Department of Cardiac Surgery, University Hospital Basel, 4031 Basel, Switzerland.; Department of Biomedicine, University of Basel, 4031 Basel, Switzerland., Magarotto F; Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.; Institute of Pediatric Research, Città della Speranza, 35127 Padova, Italy., Marsano A; Department of Cardiac Surgery, University Hospital Basel, 4031 Basel, Switzerland.; Department of Biomedicine, University of Basel, 4031 Basel, Switzerland., Pozzobon M; Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.; Institute of Pediatric Research, Città della Speranza, 35127 Padova, Italy. |
| Abstrakt: |
Large-scale muscle injury in humans initiates a complex regeneration process, as not only the muscular, but also the vascular and neuro-muscular compartments have to be repaired. Conventional therapeutic strategies often fall short of reaching the desired functional outcome, due to the inherent complexity of natural skeletal muscle. Tissue engineering offers a promising alternative treatment strategy, aiming to achieve an engineered tissue close to natural tissue composition and function, able to induce long-term, functional regeneration after in vivo implantation. This review aims to summarize the latest approaches of tissue engineering skeletal muscle, with specific attention toward fabrication, neuro-angiogenesis, multicellularity and the biochemical cues that adjuvate the regeneration process. |
