Potentially fatal complications of systemic air embolism after computed tomography-guided transthoracic needle biopsy in lung cancer harboring epithelial growth factor receptor mutation: A case report.

Autor: Oh HJ; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea., Jeong WG; Department of Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea., Lim Y; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea., Koh SJ; Department of Neurology, Chonnam National University Medical School, Gwangju, Republic of Korea., Lee SM; Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea., Kim MS; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea., Koh BG; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea., Kim TO; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea., Choi YD; Department of Pathology, Chonnam National University Medical School, Gwangju, Republic of Korea., Oh IJ; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea., Kim YC; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea., Park CK; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea.
Jazyk: angličtina
Zdroj: Thoracic cancer [Thorac Cancer] 2020 Nov; Vol. 11 (11), pp. 3401-3406. Date of Electronic Publication: 2020 Oct 02.
DOI: 10.1111/1759-7714.13686
Abstrakt: Air embolism is a rare, fatal complication of computed tomography (CT)-guided transthoracic needle biopsy (TTNB) of the lung. Here, we report a patient who developed an air embolism after CT-guided TTNB, which led to ST-elevation myocardial infarction and acute cerebral ischemia. The patient recovered completely without critical sequelae and was diagnosed with adenocarcinoma harboring activating epidermal growth factor receptor (EGFR) mutation. The patient responded to subsequent treatment with gefitinib. KEY POINTS: SIGNFICANT FINDINGS OF THE STUDY: Air embolism is a rare, fatal complication of CT-guided transthoracic lung biopsy. Only a few cases have been previously reported where myocardial and cerebral infarction occurred after TTNB, demonstrated not only on CT scan, but also electrocardiogram and electroencephalogram. WHAT THIS STUDY ADDS: Detection of driver gene mutation is crucial for planning lung cancer treatment. Despite the need for tissue biopsy, air embolism propagation to vital organs could result in severe end-organ damage and multidisciplinary approaches are needed to improve initial outcomes.
(© 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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